A Comparative Study of Metformin and Nicotinamide Riboside in Alleviating Tissue Aging in Rats

Overview

Journal Life Med

Date 2025 Jan 28

PMID 39872949

Authors

Lingling Geng

Bin Zhang

Haisong Liu

Si Wang

Yusheng Cai

Kuan Yang

Zhiran Zou

Xiaoyu Jiang

Zunpeng Liu

Wei Li

Zeming Wu

Xiaoqian Liu

Qun Chu

Guang-Hui Liu

Jing Qu

Weiqi Zhang

Affiliations

Soon will be listed here.

Abstract

Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR regulate the aging program and delay aging in multiple tissues remains unclear. Here, we demonstrated that MET and NR attenuate aging features in human mesenchymal stem cells. Moreover, by systematically investigating the pathophysiological changes in different tissues from aged rats after oral administration of MET and NR, we showed that both MET and NR treatment alleviated various aging-related characteristics in multiple tissues, including inflammation, fibrosis, and protein aggregates. Consistently, MET or NR treatment partially rescued aging-related gene expression changes in aged rats. Collectively, we report that both MET and NR attenuate senescence phenotypes in human stem cells and in a variety of rodent tissues , thus providing a valuable resource and foundation for further evaluation of these two compounds against aging.

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