Circulating Autoantibodies Against Neuroblastoma Suppressor of Tumorigenicity 1 (NBL1): A Potential Biomarker for Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 30

PMID 29596467

Citations 11

Authors

Takuma Matsumura

Jiro Terada

Taku Kinoshita

Yoriko Sakurai

Misuzu Yahaba

Kenji Tsushima

Seiichiro Sakao

Kengo Nagashima

Toshinori Ozaki

Yoshio Kobayashi

Takaki Hiwasa

Koichiro Tatsumi

Affiliations

Soon will be listed here.

Abstract

Objective: Although severe obstructive sleep apnea (OSA) is an important risk factor for atherosclerosis-related diseases including coronary artery disease (CAD), there is no reliable biomarker of CAD risks in patients with OSA. This study aimed to test our hypothesis that circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1-Abs) are associated with the prevalence of CAD in patients with OSA.

Methods: Eighty-two adults diagnosed with OSA by polysomnography, 96 patients with a diagnosis of acute coronary syndrome (ACS) and 64 healthy volunteers (HVs) were consecutively enrolled. Serum samples were collected from patients with OSA at diagnostic polysomnography and from patients with ACS at disease onset. Serum NBL1-Ab level was measured by amplified luminescence proximity homogeneous assay and its association with clinical variables related to atherosclerosis was evaluated.

Results: NBL1-Ab level was significantly elevated in patients with both OSA and ACS compared with HVs. Subgroup analyses showed that NBL1-Ab level was markedly higher in patients with severe OSA and OSA patients with a history of CAD. Weak associations were observed between NBL1-Ab level and apnea-hypopnea index, age, mean SpO2 and arousal index, whereas significantly higher NBL1-Ab levels were observed in OSA patients with a history of CAD than in those without a history of CAD. Sensitivity analysis using a logistic regression model also demonstrated that increased NBL1-Ab levels were associated with the previous history of CAD in patients with OSA.

Conclusions: Elevated NBL1-Ab levels may be associated with the prevalence of CAD in patients with OSA, which needs to be confirmed further.

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