Circulating Anti-Sorting Nexins 16 Antibodies As an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2020 Feb 5

PMID 32012743

Citations 5

Authors

Yusuke Katsumata

Jiro Terada

Takuma Matsumura

Ken Koshikawa

Seiichiro Sakao

Go Tomiyoshi

Natsuko Shinmen

Rika Nakamura

Hideyuki Kuroda

Kengo Nagashima

Yoshio Kobayashi

Eiichi Kobayashi

Yasuo Iwadate

Xiao-Meng Zhang

Takaki Hiwasa

Koichiro Tatsumi

Affiliations

Soon will be listed here.

Abstract

Biomarkers are not available for monitoring the onset and progression of coronary artery disease (CAD) in patients with obstructive sleep apnea (OSA), a major risk factor for arteriosclerotic cardiovascular diseases. This study aimed to test for correlation between circulating anti-Sorting Nexins 16 antibody (SNX16-Ab) levels, CAD history and clinical parameters of patients with OSA. Sixty-four healthy donors, 82 adults with OSA, and 96 with acute coronary syndrome (ACS) were studied. Serum samples were collected at diagnostic polysomnography in the OSA group or at the disease onset in the ACS group. Serum SNX16-Ab levels were measured by amplified luminescence proximity homogeneous assay (AlphaLISA), and correlation between SNX16-Ab levels and clinical parameters was analyzed. SNX16-Ab levels and apnea-hypopnea index (AHI) were weakly correlated. Additionally, logistic regression analyses of OSA group identified that elevated SNX16-Ab level associated with the history of CAD. Circulating SNX16-Ab could increase during CAD pathogenesis in patients with OSA. Further prospective studies are required to prove the predictive potential of SNX16-Ab level in CAD onset of patients with OSA.

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References

Drager L, Polotsky V, Lorenzi-Filho G . Obstructive sleep apnea: an emerging risk factor for atherosclerosis. Chest. 2011; 140(2):534-542. PMC: 3198492. DOI: 10.1378/chest.10-2223. View

Wang L, Huang Z, Huang W, Chen X, Shan P, Zhong P . Inhibition of epidermal growth factor receptor attenuates atherosclerosis via decreasing inflammation and oxidative stress. Sci Rep. 2017; 8:45917. PMC: 5379239. DOI: 10.1038/srep45917. View

Somers V, White D, Amin R, Abraham W, Costa F, Culebras A . Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee,.... J Am Coll Cardiol. 2008; 52(8):686-717. DOI: 10.1016/j.jacc.2008.05.002. View

Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa S, Cenic-Milosevic D . Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2014; 52(2):70-85. DOI: 10.3109/10408363.2014.992063. View

Randerath W, Bonsignore M, Herkenrath S . Obstructive sleep apnoea in acute coronary syndrome. Eur Respir Rev. 2019; 28(153). PMC: 9488646. DOI: 10.1183/16000617.0114-2018. View

Arnaud C, Dematteis M, Pepin J, Baguet J, Levy P . Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin Immunopathol. 2009; 31(1):113-25. PMC: 3937574. DOI: 10.1007/s00281-009-0148-5. View

Machida T, Kubota M, Kobayashi E, Iwadate Y, Saeki N, Yamaura A . Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). J Transl Med. 2015; 13:71. PMC: 4344740. DOI: 10.1186/s12967-015-0393-4. View

Marshall N, Wong K, Liu P, Cullen S, Knuiman M, Grunstein R . Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008; 31(8):1079-85. PMC: 2542953. View

Iseme R, McEvoy M, Kelly B, Agnew L, Walker F, Handley T . A role for autoantibodies in atherogenesis. Cardiovasc Res. 2017; 113(10):1102-1112. DOI: 10.1093/cvr/cvx112. View

10.

Liu A, Lamendola C, Ariel D, Abbasi F, Kim S, Cardell J . Usefulness of fetuin-A to predict risk for cardiovascular disease among patients with obstructive sleep apnea. Am J Cardiol. 2015; 116(2):219-24. PMC: 4475487. DOI: 10.1016/j.amjcard.2015.04.014. View

11.

Hartley A, Haskard D, Khamis R . Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - Novel insights and future directions in diagnosis and therapy<sup/>. Trends Cardiovasc Med. 2018; 29(1):22-26. DOI: 10.1016/j.tcm.2018.05.010. View

12.

Galovic R, Flegar-Mestric Z, Vidjak V, Matokanovic M, Barisic K . Heat shock protein 70 and antibodies to heat shock protein 60 are associated with cerebrovascular atherosclerosis. Clin Biochem. 2015; 49(1-2):66-9. DOI: 10.1016/j.clinbiochem.2015.10.006. View

13.

Nadeem R, Singh M, Nida M, Kwon S, Sajid H, Witkowski J . Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. J Clin Sleep Med. 2014; 10(12):1295-302. PMC: 4237522. DOI: 10.5664/jcsm.4282. View

14.

Choi J, Hong W, Kim M, Kim J, Ryu S, Suh P . Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J Cell Sci. 2004; 117(Pt 18):4209-18. DOI: 10.1242/jcs.01233. View

15.

Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M . European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted.... Eur Heart J. 2012; 33(13):1635-701. DOI: 10.1093/eurheartj/ehs092. View

16.

Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Ema R . Circulating Anti-Coatomer Protein Complex Subunit Epsilon (COPE) Autoantibodies as a Potential Biomarker for Cardiovascular and Cerebrovascular Events in Patients with Obstructive Sleep Apnea. J Clin Sleep Med. 2016; 13(3):393-400. PMC: 5337586. DOI: 10.5664/jcsm.6488. View

17.

Fava C, Dorigoni S, Dalle Vedove F, Danese E, Montagnana M, Guidi G . Effect of CPAP on blood pressure in patients with OSA/hypopnea a systematic review and meta-analysis. Chest. 2013; 145(4):762-771. DOI: 10.1378/chest.13-1115. View

18.

Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Tsushima K . Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea. PLoS One. 2018; 13(3):e0195015. PMC: 5875805. DOI: 10.1371/journal.pone.0195015. View

19.

Zhang H, Chalothorn D, Jackson L, Lee D, Faber J . Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circ Res. 2004; 95(10):989-97. DOI: 10.1161/01.RES.0000147962.01036.bb. View

20.

Marin J, Carrizo S, Vicente E, Agusti A . Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005; 365(9464):1046-53. DOI: 10.1016/S0140-6736(05)71141-7. View