Microbial Symbionts Regulate the Primary Ig Repertoire

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2018 Mar 29

PMID 29588346

Citations 27

Authors

Yuezhou Chen

Neha Chaudhary

Nicole Yang

Alessandra Granato

Jacob A Turner

Shannon L Howard

Colby Devereaux

Teng Zuo

Akritee Shrestha

Rishi R Goel

Donna Neuberg

Duane R Wesemann

Affiliations

Soon will be listed here.

Abstract

The ability of immunoglobulin (Ig) to recognize pathogens is critical for optimal immune fitness. Early events that shape preimmune Ig repertoires, expressed on IgM IgD B cells as B cell receptors (BCRs), are poorly defined. Here, we studied germ-free mice and conventionalized littermates to explore the hypothesis that symbiotic microbes help shape the preimmune Ig repertoire. Ig-binding assays showed that exposure to conventional microbial symbionts enriched frequencies of antibacterial IgM IgD B cells in intestine and spleen. This enrichment affected follicular B cells, involving a diverse set of Ig-variable region gene segments, and was T cell-independent. Functionally, enrichment of microbe reactivity primed basal levels of small intestinal T cell-independent, symbiont-reactive IgA and enhanced systemic IgG responses to bacterial immunization. These results demonstrate that microbial symbionts influence host immunity by enriching frequencies of antibacterial specificities within preimmune B cell repertoires and that this may have consequences for mucosal and systemic immunity.

Citing Articles

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