Antigen Discovery Tools for Adaptive Immune Receptor Repertoire Research

Overview

Journal Curr Opin Syst Biol

Date 2020 Nov 16

PMID 33195881

Citations 2

Authors

Djenet Bousbaine

Hidde L Ploegh

Affiliations

Soon will be listed here.

Abstract

The adaptive immune system has evolved to recognize with incredible precision a large diversity of molecules. Innovations in high-throughput sequencing and bioinformatics have accelerated large-scale immune repertoire analyses and given us important insights into the behavior of the adaptive immune system. However, establishing a connection between receptor sequence and its antigen-specificity remains a challenge despite its central role in determining T and B cell fate. We discuss recent large-scale antigen discovery technologies which can be combined with adaptive immune receptor repertoire (AIRR) studies. We highlight important discoveries made using repertoire analyses in the field of host-microbe interactions.

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