Six Heterocyclic Metabolites from the Myxobacterium Labilithrix Luteola

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Mar 3

PMID 29495640

Citations 14

Authors

Lucky S Mulwa

Rolf Jansen

Dimas F Praditya

Kathrin I Mohr

Joachim Wink

Eike Steinmann

Marc Stadler

Affiliations

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Abstract

Two new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] () and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (), were isolated from the myxobacterium (DSM 27648). Additionally, four metabolites , , and already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal ¹H-NMR coupling data. The compounds where tested for biological activities; labindoles A () and B () exhibited significant activity against Hepatitis C Virus, 9-carbazole (), 3-chloro-9-carbazole () and 4-hydroxymethyl-quinoline () showed antifungal activities. Moreover, compound had weak to moderate antibacterial activities, while labindoles A () and B () were devoid of significant antifungal and antibacterial effects.

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