Aetheramides A and B, Potent HIV-inhibitory Depsipeptides from a Myxobacterium of the New Genus "Aetherobacter"

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 May 24

PMID 22616796

Citations 16

Authors

Alberto Plaza

Ronald Garcia

Giuseppe Bifulco

Javier Pablo Martinez

Stephan Huttel

Florenz Sasse

Andreas Meyerhans

Marc Stadler

Rolf Muller

Affiliations

Soon will be listed here.

Abstract

Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT-116) cells with IC(50) values of 0.11 μM.

Citing Articles

Recent advances on cyclodepsipeptides: biologically active compounds for drug research.

Liu S, Ou-Yang S, Lu Y, Guo C, Dai S, Li C Front Microbiol. 2023; 14:1276928.

PMID: 37849925 PMC: 10577210. DOI: 10.3389/fmicb.2023.1276928.

Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19.

Raihan T, Rabbee M, Roy P, Choudhury S, Baek K, Azad A Front Mol Biosci. 2021; 8:732256.

PMID: 34557521 PMC: 8452873. DOI: 10.3389/fmolb.2021.732256.

Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study.

Bhat M, Mishra A, Bhat M, Banday M, Bashir O, Rather I Pharmaceutics. 2021; 13(8).

PMID: 34452226 PMC: 8401837. DOI: 10.3390/pharmaceutics13081265.

Myxobacteria and their products: current trends and future perspectives in industrial applications.

Shrivastava A, Sharma R Folia Microbiol (Praha). 2021; 66(4):483-507.

PMID: 34060028 DOI: 10.1007/s12223-021-00875-z.

Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020.

Okoth D, Hug J, Mandi A, Kurtan T, Garcia R, Muller R J Ind Microbiol Biotechnol. 2021; 48(3-4).

PMID: 34003283 PMC: 9113121. DOI: 10.1093/jimb/kuab029.