Flavonoid Intake from Fruit and Vegetables During Adolescence is Prospectively Associated with a Favourable Risk Factor Profile for Type 2 Diabetes in Early Adulthood

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2018 Feb 23

PMID 29468461

Citations 16

Authors

Katharina J Penczynski

Christian Herder

Danika Krupp

Johanna Rienks

Sarah Egert

Stefan A Wudy

Michael Roden

Thomas Remer

Anette E Buyken

Affiliations

Soon will be listed here.

Abstract

Purpose: Flavonoid consumption during adolescence could contribute to preventing adult onset of type 2 diabetes mellitus. We investigated the prospective association between habitual intake of flavonoids from fruit and vegetables (FlavFV) during adolescence and risk markers of type 2 diabetes in early adulthood.

Methods: This analysis included participants of the DONALD Study, who had provided a fasting blood sample in adulthood (18-39 years), data on FlavFV-intake during adolescence (females: 9-15 years, males: 10-16 years) and relevant covariates. Habitual FlavFV-intake was either estimated using repeated 3-day weighed dietary records (n = 268), or the validated biomarker hippuric acid (uHA)-excretion in repeated 24-h urine samples (n = 241). Multivariable linear regressions were performed to analyse the prospective associations of FlavFV or uHA with homeostasis model assessment insulin sensitivity (HOMA2-%S), hepatic steatosis index (HSI), fatty liver index (FLI) and a pro-inflammatory score.

Results: Higher FlavFV-intake was independently related to higher HOMA2-%S among females (P = 0.03), but not among males. Both FlavFV-intake and uHA-excretion were inversely associated with HSI (P < 0.0001 and P = 0.02, respectively) and the pro-inflammatory score (P = 0.02 and P = 0.008, respectively), but not with FLI.

Conclusions: Our data indicate that flavonoid consumption from fruit and vegetables during adolescence is associated with a favourable risk factor profile for type 2 diabetes in early adulthood.

Citing Articles

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Cohort profile update-overview of over 35 years of research in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study.

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Alignment between timing of 'highest caloric intake' and chronotype in relation to body composition during adolescence: the DONALD Study.

Jankovic N, Schmitting S, Stutz B, Kruger B, Buyken A, Alexy U Eur J Nutr. 2023; 63(1):253-265.

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