Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Feb 21

PMID 29459871

Citations 26

Authors

Tamara Hoppenbrouwers

Andi R Sultan

Tsion E Abraham

Nicole A Lemmens-den Toom

Silvie Hansenova Manaskova

Wiggert A van Cappellen

Adriaan B Houtsmuller

Willem J B van Wamel

Moniek P M de Maat

Johan W van Neck

Affiliations

Soon will be listed here.

Abstract

are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in -induced NETosis. We determined the Protein A production of four different strains and found a direct relationship between the degree of NETosis induction and Protein A production: strains producing higher concentrations of Protein A evoke significantly more NETs. A strain in which Protein A as well as a second binding protein for immunoglobulins () have been knocked-out (Δ Δ) induced significantly less NETosis than the wild-type strain. NETosis induction by this knockout strain can be rescued by the addition of purified Protein A. Dead did not induce NETosis. In conclusion, Protein A is a determinant for NETosis induction by .

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