The NDPK/NME Superfamily: State of the Art

Overview

Journal Lab Invest

Specialty Pathology

Date 2018 Feb 17

PMID 29451272

Citations 47

Authors

Mathieu Boissan

Uwe Schlattner

Marie-Lise Lacombe

Affiliations

Soon will be listed here.

Abstract

Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded proteins are catalytically active NDPKs and that NM23 generally refers to clinical studies on metastasis, we use here NME/NDPK to denote the proteins. Since their discovery in the 1950's, NMEs/NDPKs have been shown to be involved in multiple physiological and pathological cellular processes, but the molecular mechanisms have not been fully determined. Recent progress in elucidating these underlying mechanisms has been presented by experts in the field at the 10th International Congress on the NDPK/NME/AWD protein family in October 2016 in Dubrovnik, Croatia, and is summarized in review articles or original research in this and an upcoming issue of Laboratory Investigation. Within this editorial, we discuss three major cellular processes that involve members of the multi-functional NME/NDPK family: (i) cancer and metastasis dissemination, (ii) membrane remodeling and nucleotide channeling, and iii) protein histidine phosphorylation.

Citing Articles

Untargeted Mutation Triggered by Ribonucleoside Embedded in DNA.

Suzuki T, Yasui K, Komatsu Y, Kamiya H Int J Mol Sci. 2025; 25(24.

PMID: 39769470 PMC: 11679520. DOI: 10.3390/ijms252413708.

Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes.

Amjadi R, Werten S, Lomada S, Baldin C, Scheffzek K, Dunzendorfer-Matt T Int J Mol Sci. 2024; 25(18).

PMID: 39337255 PMC: 11431768. DOI: 10.3390/ijms25189768.

Mitochondrial NME6 Influences Basic Cellular Processes in Tumor Cells In Vitro.

Proust B, Horvat A, Tadijan A, Vlasic I, Herak Bosnar M Int J Mol Sci. 2024; 25(17).

PMID: 39273527 PMC: 11395177. DOI: 10.3390/ijms25179580.

Mitochondrial NME6: A Paradigm Change within the NME/NDP Kinase Protein Family?.

Proust B, Herak Bosnar M, Cetkovic H, Tokarska-Schlattner M, Schlattner U Cells. 2024; 13(15.

PMID: 39120309 PMC: 11312278. DOI: 10.3390/cells13151278.

Cellular energy regulates mRNA degradation in a codon-specific manner.

Tomaz da Silva P, Zhang Y, Theodorakis E, Martens L, Yepez V, Pelechano V Mol Syst Biol. 2024; 20(5):506-520.

PMID: 38491213 PMC: 11066088. DOI: 10.1038/s44320-024-00026-9.

References

Thakur R, Yadav V, Kumar A, Singh A, Pal K, Hoeppner L . Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin. Nucleic Acids Res. 2014; 42(18):11589-600. PMC: 4191424. DOI: 10.1093/nar/gku860. View

Iwashita S, Fujii M, Mukai H, Ono Y, Miyamoto M . Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. Biochem Biophys Res Commun. 2004; 320(4):1063-8. DOI: 10.1016/j.bbrc.2004.06.067. View

Aktary Z, Chapman K, Lam L, Lo A, Ji C, Graham K . Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. Oncogene. 2010; 29(14):2118-29. DOI: 10.1038/onc.2009.495. View

Norman A, Wedding R, Black M . Detection of phosphohistidine in nucleoside diphosphokinase isolated from Jerusalem artichoke mitochondria. Biochem Biophys Res Commun. 1965; 20(6):703-9. DOI: 10.1016/0006-291x(65)90073-2. View

Hippe H, Abu-Taha I, Wolf N, Katus H, Wieland T . Through scaffolding and catalytic actions nucleoside diphosphate kinase B differentially regulates basal and β-adrenoceptor-stimulated cAMP synthesis. Cell Signal. 2010; 23(3):579-85. DOI: 10.1016/j.cellsig.2010.11.010. View

Murakami M, Lan K, Subramanian C, Robertson E . Epstein-Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration. J Virol. 2005; 79(3):1559-68. PMC: 544130. DOI: 10.1128/JVI.79.3.1559-1568.2005. View

Marino N, Marshall J, Collins J, Zhou M, Qian Y, Veenstra T . Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis. Cancer Res. 2013; 73(19):5949-62. PMC: 3825031. DOI: 10.1158/0008-5472.CAN-13-0368. View

Boissan M, Lacombe M . Learning about the functions of NME/NM23: lessons from knockout mice to silencing strategies. Naunyn Schmiedebergs Arch Pharmacol. 2011; 384(4-5):421-31. DOI: 10.1007/s00210-011-0649-3. View

Lacombe M, Milon L, Munier A, Mehus J, Lambeth D . The human Nm23/nucleoside diphosphate kinases. J Bioenerg Biomembr. 2002; 32(3):247-58. DOI: 10.1023/a:1005584929050. View

10.

Morlot S, Roux A . Mechanics of dynamin-mediated membrane fission. Annu Rev Biophys. 2013; 42:629-49. PMC: 4289195. DOI: 10.1146/annurev-biophys-050511-102247. View

11.

Zala D, Schlattner U, Desvignes T, Bobe J, Roux A, Chavrier P . The advantage of channeling nucleotides for very processive functions. F1000Res. 2017; 6:724. PMC: 5473427. DOI: 10.12688/f1000research.11561.2. View

12.

Arnaud-Dabernat S, Bourbon P, Dierich A, Le Meur M, Daniel J . Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene. J Bioenerg Biomembr. 2003; 35(1):19-30. DOI: 10.1023/a:1023561821551. View

13.

Okabe-Kado J, Kasukabe T . Physiological and pathological relevance of extracellular NM23/NDP kinases. J Bioenerg Biomembr. 2003; 35(1):89-93. DOI: 10.1023/a:1023402125186. View

14.

Fiore L, Ganguly S, Sledziona J, Cibull M, Wang C, Richards D . c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer. Oncogene. 2013; 33(36):4508-4520. PMC: 3979510. DOI: 10.1038/onc.2013.399. View

15.

Hippe H, Luedde M, Lutz S, Koehler H, Eschenhagen T, Frey N . Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circ Res. 2007; 100(8):1191-9. DOI: 10.1161/01.RES.0000264058.28808.cc. View

16.

Marino N, Nakayama J, Collins J, Steeg P . Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene. Cancer Metastasis Rev. 2012; 31(3-4):593-603. PMC: 7479534. DOI: 10.1007/s10555-012-9374-8. View

17.

Leone A, Flatow U, King C, Sandeen M, Margulies I, Liotta L . Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell. 1991; 65(1):25-35. DOI: 10.1016/0092-8674(91)90404-m. View

18.

Hsu T, Adereth Y, Kose N, Dammai V . Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem. 2006; 281(17):12069-80. PMC: 2367321. DOI: 10.1074/jbc.M511621200. View

19.

Ignesti M, Barraco M, Nallamothu G, Woolworth J, Duchi S, Gargiulo G . Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biol. 2014; 12:12. PMC: 3937027. DOI: 10.1186/1741-7007-12-12. View

20.

Duran M, Vega F, Moreno-Bueno G, Artiga M, Sanchez L, Palacios J . Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer. Proteomics Clin Appl. 2010; 2(9):1313-26. DOI: 10.1002/prca.200780020. View