Kunitada Shimotohno
Overview
Explore the profile of Kunitada Shimotohno including associated specialties, affiliations and a list of published articles.
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Articles
162
Citations
4503
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Recent Articles
1.
Nishitsuji H, Naito Y, Murakami Y, Sugiyama M, Mizokami M, Shoji I, et al.
Hepatology
. 2025 Jan;
PMID: 39847392
Background And Aims: HBV leads to severe liver diseases, such as cirrhosis and HCC. Identification of host factors that regulate HBV replication can provide new therapeutic targets. The discovery of...
2.
Muchtar A, Onomura D, Ding D, Nishitsuji H, Shimotohno K, Okada S, et al.
Front Microbiol
. 2025 Jan;
15:1499216.
PMID: 39834379
Current treatments for hepatitis B virus (HBV), such as interferons and nucleic acid analogs, have limitations due to side effects like depression and the development of drug-resistant mutants, highlighting the...
3.
Murayama A, Igarashi H, Yamada N, Aly H, Molchanova N, Lin J, et al.
Antiviral Res
. 2024 Jan;
223:105821.
PMID: 38272318
Although antimicrobial peptides have been shown to inactivate viruses through disruption of their viral envelopes, clinical use of such peptides has been hampered by a number of factors, especially their...
4.
Kamijo S, Kawaguchi Y, Fujii H, Sakaguchi B, Doira H, Kuhara S, et al.
Dev Growth Differ
. 2023 Jun;
20(4):283-289.
PMID: 37281729
The mucous glands of Bombyx pupae secrete glue proteins which attach deposited eggs to the mounting sheet. A mutant of a dominant gene, named no glue (Ng), produces nonadhesive eggs...
5.
Murata T, Iwahori S, Okuno Y, Nishitsuji H, Yanagi Y, Watashi K, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768585
N6-methyladenosine (mA) is a post-transcriptional modification of RNA involved in transcript transport, degradation, translation, and splicing. We found that HBV RNA is modified by mA predominantly in the coding region...
6.
Yato K, Matsuda M, Fukano K, Tanaka T, Moriishi K, Nishitsuji H, et al.
Virus Res
. 2022 Dec;
323:199014.
PMID: 36511290
Hepatitis B virus (HBV) infection is a major public health problem. The sodium taurocholate cotransporting polypeptide (NTCP) has been identified as an essential HBV receptor. Human hepatocytes are infected with...
7.
Fujita K, Nishitsuji H, Iwama H, Tadokoro T, Morishita A, Mimura S, et al.
Gene
. 2022 Nov;
853:147068.
PMID: 36427676
Hepatitis B virus (HBV) infection is one of the most serious global health problems. Our previous data using an in vitro assay revealed that miR-6126 suppressed the extracellular HBs antigen...
8.
Washizaki A, Murayama A, Murata M, Kiyohara T, Yato K, Yamada N, et al.
Nat Commun
. 2022 Sep;
13(1):5207.
PMID: 36064848
Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We...
9.
Nishitsuji H, Iwahori S, Ohmori M, Shimotohno K, Murata T
mBio
. 2022 Jul;
13(4):e0097122.
PMID: 35856559
Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory cytokines, which eventually lead to cytokine storm and the development of acute respiratory distress syndrome. However, the...
10.
Gad S, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al.
PLoS Pathog
. 2022 Mar;
18(3):e1009983.
PMID: 35312737
Intracellular transport via microtubule-based dynein and kinesin family motors plays a key role in viral reproduction and transmission. We show here that Kinesin Family Member 4 (KIF4) plays an important...