Simon B Blakey
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Explore the profile of Simon B Blakey including associated specialties, affiliations and a list of published articles.
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32
Citations
217
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Recent Articles
1.
Lester C, Li J, Passang T, Wang Y, Waller E, Blakey S
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673976
Antagonist peptides (ANTs) of vasoactive intestinal polypeptide receptors (VIP-Rs) are shown to enhance T cell activation and proliferation in vitro, as well as improving T cell-dependent anti-tumor response in acute...
2.
Maust M, Blakey S
ACS Catal
. 2024 Feb;
14(4):2582-2587.
PMID: 38384944
Modern organic synthesis requires methodologies that bring together abundant feedstock chemicals in a mild and efficient manner. To aid in this effort, we have developed a multicomponent radical hydroxyarylation reaction...
3.
Gross P, Im H, Laws 3rd D, Park B, Baik M, Blakey S
J Am Chem Soc
. 2024 Jan;
146(2):1447-1454.
PMID: 38170978
Chiral aziridines are important structural motifs found in natural products and various target molecules. They serve as versatile building blocks for the synthesis of chiral amines. While advances in catalyst...
4.
Laws 3rd D, Poff C, Heyboer E, Blakey S
Chem Soc Rev
. 2023 Aug;
52(17):6003-6030.
PMID: 37554058
Planar chirality is an important form of molecular chirality that can be utilized to induce enantioselectivity when incorporated into transition metal catalysts. However, due to synthetic constraints, the use of...
5.
Hendy C, Pratt C, Jui N, Blakey S
Org Lett
. 2023 Feb;
25(9):1397-1402.
PMID: 36848497
Here, we report an efficient and modular approach toward the formation of difluorinated arylethylamines from simple aldehyde-derived -dialkylhydrazones and trifluoromethylarenes (CF-arenes). This method relies on selective C-F bond cleavage via...
6.
Laws 3rd D, Plouch E, Blakey S
J Nat Prod
. 2022 Sep;
85(10):2519-2539.
PMID: 36136399
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are known for their macrocyclic structures, which impart unique biological activity. One rapidly emerging subclass of RiPP natural products contains macrocyclic C-C cross-links...
7.
Maust M, Hendy C, Jui N, Blakey S
J Am Chem Soc
. 2022 Feb;
144(9):3776-3781.
PMID: 35200024
Controlling the regioselectivity of radical cyclizations to favor the 6- mode over its kinetically preferred 5- counterpart is difficult without introducing substrate prefunctionalization. To address this challenge, we have developed...
8.
Shi Q, Shi X, Feng C, Wu Y, Zheng N, Liu J, et al.
Angew Chem Int Ed Engl
. 2020 Oct;
60(6):2924-2928.
PMID: 33107179
Synthetic routes for heteroatom-containing polycyclic aromatic hydrocarbons (H-PAHs) with alkyl and aryl substitution are demonstrated. Three H-PAHs, including heteroatom-containing rubicenes (H-rubicenes), angular-benzothiophenes (ABTs), and indenothiophene (IDTs) were successfully synthesized by...
9.
Kazerouni A, McKoy Q, Blakey S
Chem Commun (Camb)
. 2020 Oct;
56(87):13287-13300.
PMID: 33015689
Allylic substitution, pioneered by the work of Tsuji and Trost, has been an invaluable tool in the synthesis of complex molecules for decades. An attractive alternative to allylic substitution is...
10.
Nelson T, Hollerbach M, Blakey S
Dalton Trans
. 2020 Sep;
49(40):13928-13935.
PMID: 32909583
Allylic C-H functionalization catalysed by group 9 Cp* transition-metal complexes has recently gained significant attention. These reactions have expanded allylic C-H functionalization to include di- and trisubstituted olefins, and a...