Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2018 Feb 14

PMID 29434409

Citations 10

Authors

Na Shi

Lihui Deng

Weiwei Chen

Xiaoxin Zhang

Ruijie Luo

Tao Jin

Yun Ma

Chen Du

Ziqi Lin

Kun Jiang

Jia Guo

Xiaonan Yang

Qing Xia

Affiliations

Soon will be listed here.

Abstract

Background And Aims: The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI).

Methods: Rats were administrated with retrograde cholangiopancreatography injection of 0.5% or 3.5% sodium taurocholate to induce AP with mild or severe LI and were sacrificed at 6, 12, and 24 h. Rats from the control group received a laparotomy only. Plasma from a prospective cohort of AP patients was collected. The levels of miR-127 in the tissues and plasma were detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

Results: The upregulation of miR-127 in the lungs of rats was detected in the groups of AP with severe LI at 6 h and 24 h, whereas it was scarcely detectable in plasma. In the pilot study that included 18 AP patients and 5 healthy volunteers, the plasma miR-127 level was significantly downregulated in AP patients with respiratory failure compared with the healthy volunteers ( = 0.014) and those without respiratory failure ( = 0.043).

Conclusion: miR-127 might serve as a potential marker for the identification of AP with LI.

Citing Articles

Personalized medicine using omics approaches in acute respiratory distress syndrome to identify biological phenotypes.

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Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury.

Yang Q, Luo Y, Lan B, Dong X, Wang Z, Ge P Bioengineering (Basel). 2022; 9(11).

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New challenges for microRNAs in acute pancreatitis: progress and treatment.

Zhou W, Dong S, Chen Z, Li X, Jiang W J Transl Med. 2022; 20(1):192.

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Gut microbiome in acute pancreatitis: A review based on current literature.

Patel B, Patel K, Bhatia M, Iyer S, Madhavan K, Moochhala S World J Gastroenterol. 2021; 27(30):5019-5036.

PMID: 34497432 PMC: 8384740. DOI: 10.3748/wjg.v27.i30.5019.

miR-133b has protective effect on rats with acute lung injury caused by severe acute pancreatitis through targeting sp1 gene.

Weng Y, Lin N, Yin L, Liu A Int J Clin Exp Pathol. 2021; 14(1):86-96.

PMID: 33532026 PMC: 7847488.

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