Vgll3 and the Hippo Pathway Are Regulated in Sertoli Cells Upon Entry and During Puberty in Atlantic Salmon Testis

Overview

Journal Sci Rep

Specialty Science

Date 2018 Feb 1

PMID 29382956

Citations 17

Authors

Erik Kjaerner-Semb

Fernando Ayllon

Lene Kleppe

Elin Sorhus

Kai Skaftnesmo

Tomasz Furmanek

Frida T Segafredo

Anders Thorsen

Per Gunnar Fjelldal

Tom Hansen

Geir Lasse Taranger

Eva Andersson

Rudiger W Schulz

Anna Wargelius

Rolf B Edvardsen

Affiliations

Soon will be listed here.

Abstract

Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 and the associated Hippo pathway has been linked to reduced proliferation activity in different tissues. Analysis of gene expression reveals for the first time that vgll3 and several members of the Hippo pathway were down-regulated in salmon testis during onset of puberty and remained repressed in maturing testis. In the gonads, we found expression in Sertoli and granulosa cells in males and females, respectively. We hypothesize that vgll3 negatively regulates Sertoli cell proliferation in testis and therefore acts as an inhibitor of pubertal testis growth. Gonadal expression of vgll3 is located to somatic cells that are in direct contact with germ cells in both sexes, however our results indicate sex-biased regulation of vgll3 during puberty.

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