Disease Implications of the Hippo/YAP Pathway

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2015 Feb 24

PMID 25702974

Citations 137

Authors

Steven W Plouffe

Audrey W Hong

Kun-Liang Guan

Affiliations

Soon will be listed here.

Abstract

The Hippo signaling pathway is important for controlling organ size and tissue homeostasis. Originally identified in Drosophila melanogaster, the core components of the Hippo pathway are highly conserved in mammals. The Hippo pathway can be modulated by a wide range of stimuli, including G protein-coupled receptor (GPCR) signaling, changes in the actin cytoskeleton, cell-cell contact, and cell polarity. When activated, the Hippo pathway functions as a tumor suppressor to limit cell growth. However, dysregulation by genetic inactivation of core pathway components or amplification or gene fusion of its downstream effectors results in increased cell proliferation and decreased apoptosis and differentiation. Unsurprisingly, this can lead to tissue overgrowth, tumorigenesis, and many other diseases.

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