PAX-5 Positive Anaplastic Large Cell Lymphoma Presenting by Dysphagia; a Case Report

Overview

Journal Gastroenterol Hepatol Bed Bench

Specialty Gastroenterology

Date 2018 Jan 31

PMID 29379600

Citations 1

Authors

Negar Azarpira

Akbar Safaie

Ahmad Monabati

Masudd Hosseinzadeh

Sadat Noori

Maryam Moini

Alireza Rahimi

Tahereh Heidari

Marjan Rahsaz

Affiliations

Soon will be listed here.

Abstract

Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin lymphoma of esophagus.

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