A Case of Primary Low Grade Mucosa Associated Lymphoid Tissue (MALT) Lymphoma of the Oesophagus

Overview

Journal Gut

Specialty Gastroenterology

Date 2002 Jul 16

PMID 12117895

Citations 20

Authors

S Hosaka

N Nakamura

T Akamatsu

T Fujisawa

Y OGIWARA

K Kiyosawa

E Hidaka

H Ota

T Katsuyama

H Inagaki

Affiliations

Soon will be listed here.

Abstract

We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells--that is, centrocyte-like cells--which were stained with CD20, L26, BCL-2, and kappa, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis.

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References

Oguzkurt L, Karabulut N, Cakmakci E, Besim A . Primary non-Hodgkin's lymphoma of the esophagus. Abdom Imaging. 1997; 22(1):8-10. DOI: 10.1007/s002619900129. View

Gupta N, Goenka M, Jindal A, Behera A, Vaiphei K . Primary lymphoma of the esophagus. J Clin Gastroenterol. 1996; 23(3):203-6. DOI: 10.1097/00004836-199610000-00009. View

Ott G, Katzenberger T, Greiner A, Kalla J, Rosenwald A, Heinrich U . The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT-) type. Cancer Res. 1997; 57(18):3944-8. View

Gelb A, Medeiros L, Chen Y, Weiss L, Weidner N . Hodgkin's disease of the esophagus. Am J Clin Pathol. 1997; 108(5):593-8. DOI: 10.1093/ajcp/108.5.593. View

Yatabe Y, Nakamura S, Nakamura T, Seto M, Ogura M, Kimura M . Multiple polypoid lesions of primary mucosa-associated lymphoid-tissue lymphoma of colon. Histopathology. 1998; 32(2):116-25. DOI: 10.1046/j.1365-2559.1998.00315.x. View

Hosaka S, Akamatsu T, Nakamura S, Kaneko T, Kitano K, Kiyosawa K . Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy 3. Am J Gastroenterol. 1999; 94(7):1951-4. DOI: 10.1111/j.1572-0241.1999.01237.x. View

Caruso R, Berk R . Lymphoma of the esophagus. Radiology. 1970; 95(2):381-2. DOI: 10.1148/95.2.381. View

Nissan S, Levy E . Lymphosarcoma of the esophagus: a case report. Cancer. 1974; 34(4):1321-3. DOI: 10.1002/1097-0142(197410)34:4<1321::aid-cncr2820340444>3.0.co;2-q. View

Carnovale R, GOLDSTEIN H, Zornoza J, Dodd G . Radiologic manifestations of esophageal lymphoma. AJR Am J Roentgenol. 1977; 128(5):751-4. DOI: 10.2214/ajr.128.5.751. View

10.

Berman M, Falchuk K, TREY C, GRAMM H . Primary histiocytic lymphoma of the esophagus. Dig Dis Sci. 1979; 24(11):883-6. DOI: 10.1007/BF01324907. View

11.

BRADY L, Asbell S . Malignant lymphoma of the gastrointestinal tract. Erskine Memorial Lecture, 1979. Radiology. 1980; 137(2):291-8. DOI: 10.1148/radiology.137.2.7001537. View

12.

Isaacson P, Wright D . Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983; 52(8):1410-6. DOI: 10.1002/1097-0142(19831015)52:8<1410::aid-cncr2820520813>3.0.co;2-3. View

13.

Doki T, Hamada S, Murayama H, Suenaga H, Sannohe Y . Primary malignant lymphoma of the esophagus. A case report. Endoscopy. 1984; 16(5):189-92. DOI: 10.1055/s-2007-1018579. View

14.

Matsuura H, Saito R, Nakajima S, Yoshihara W, Enomoto T . Non-Hodgkin's lymphoma of the esophagus. Am J Gastroenterol. 1985; 80(12):941-6. View

15.

Alpen B, Neubauer A, Dierlamm J, Marynen P, Thiede C, Bayerdorfer E . Translocation t(11;18) absent in early gastric marginal zone B-cell lymphoma of MALT type responding to eradication of Helicobacter pylori infection. Blood. 2000; 95(12):4014-5. View

16.

Liu H, Lavergne-Slove A, Ye H, Molina T, Bouhnik Y, Hamoudi R . Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet. 2001; 357(9249):39-40. DOI: 10.1016/S0140-6736(00)03571-6. View

17.

Nagrani M, Lavigne B, Siskind B, Knisley R, Traube M . Primary non-Hodgkin's lymphoma of the esophagus. Arch Intern Med. 1989; 149(1):193-5. View

18.

Mengoli M, Marchi M, Rota E, Bertolotti M, Gollini C, Signorelli S . Primary non-Hodgkin's lymphoma of the esophagus. Am J Gastroenterol. 1990; 85(6):737-41. View

19.

Tsukada T, Ohno T, Kihira H, Taniguchi M, Takahashi T, Arima S . Primary esophageal non-Hodgkin's lymphoma. Intern Med. 1992; 31(4):569-72. DOI: 10.2169/internalmedicine.31.569. View

20.

Maipang T, Panjapiyakul C, Sriplung H . Primary lymphoma of the esophagus: a case report. J Med Assoc Thai. 1992; 75(5):299-303. View