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Primary Esophageal CD30-positive ALK-positive Anaplastic Large Cell Lymphoma: a Case Report and Literature Review

Overview
Journal J Gastrointest Cancer
Publisher Springer
Specialties Gastroenterology
Oncology
Date 2010 Jun 5
PMID 20524084
Citations 7
Authors
Ning Wu
Liewen Pang
Zhiming Chen
Yiqing Wang
Qinyun Ma
Gang Chen
Ji Chen
Jiechun Huang
Affiliations
Soon will be listed here.
Abstract

Purpose: To introduce a case of primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma (ALCL) and discuss its diagnosis and treatment.

Methods: Esophagectomy was done for a 37-year-old male with a submucosal lesion after a frozen section failed to give a definite diagnosis. Samples were sent for hematoxylin-eosin staining and immunohistochemical analysis. Six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy were given and the patient was followed up.

Results: The operation was uneventful. Postoperative pathologic and immunohistochemical examination yielded a diagnosis of primary CD30-positive and ALK-positive ALCL of the esophagus. The patient was in complete remission at the 14-month follow-up.

Conclusions: ALCL of the esophagus should be considered in the differential diagnosis of esophageal submucosal lesions. Biopsy through either esophagoscopy or surgical exploration, chemotherapy, and radiotherapy can be chosen for long-term survival.

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Successful treatment of post chemotherapy esophageal cicatricial atresia in a pediatric patient with anaplastic large cell lymphoma through minimally invasive esophagectomy: a case report.

Hozaka Y, Sasaki K, Nishikawa T, Onishi S, Noda M, Tsuruda Y Surg Case Rep. 2021; 7(1):41.

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