Extra Vitamin D from Fortification and the Risk of Preeclampsia: The D-tect Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jan 26

PMID 29370249

Citations 5

Authors

Maria Stougaard

Peter Damm

Peder Frederiksen

Ramune Jacobsen

Berit Lilienthal Heitmann

Affiliations

Soon will be listed here.

Abstract

The objective of the study was to examine if exposure to extra vitamin D from food fortification was associated with a decrease in the risk of preeclampsia. The study was based on a natural experiment exploring the effect of the abolition of the Danish mandatory vitamin D fortification of margarine in 1985. The effect of the extra vitamin D (1.25μg vitamin D/100 g margarine) was examined by comparing preeclampsia risk in women who have been exposed or unexposed to extra vitamin D from the fortified margarine during pregnancy, and who gave birth in the period from June 1983 to August 1988. The Danish National Patient Registry allowed the identification of pregnancies complicated by preeclampsia. The study included 73,237 women who gave birth during 1983-1988. We found no association between exposure to vitamin D fortification during pregnancy and the risk of any of the pregnancy related hypertensive disorders, including preeclampsia: Odds ratios (OR, 95%) for all hypertensive pregnancy related disorders among exposed vs. unexposed women was (OR 1.04, 95%CI: 0.98,1.10). In conclusion, the extra vitamin D from the mandatory vitamin D fortification did not influence the risk of preeclampsia.

Citing Articles

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Knowledge, attitudes, and practices associated with vitamin D supplementation: A cross-sectional online community survey of adults in the UK.

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Assessing Health Consequences of Vitamin D Fortification Utilizing a Societal Experiment Design: Methodological Lessons Learned from the D-Tect Project.

Handel M, Jacobsen R, Thorsteinsdottir F, Keller A, Stougaard M, Jensen C Int J Environ Res Public Health. 2021; 18(15).

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The role of vitamin D in perinatology. An up-to-date review.

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