The Role of Vitamin D in Perinatology. An Up-to-date Review

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2021 Aug 2

PMID 34336027

Citations 5

Authors

Michal Ciebiera

Cezary Wojtyla

Krzysztof Lukaszuk

Magdalena Zgliczynska

Kornelia Zareba

Wojciech Rawski

Grzegorz Jakiel

Affiliations

Soon will be listed here.

Abstract

The role of vitamin D in perinatology is a subject of major interest in current medicine. There is growing evidence about the role of maternal vitamin D levels in pregnancy outcomes. The aim of this review is to summarize the current literature about the role of vitamin D in perinatology. Evidence from this review suggests associations between low levels of maternal vitamin D and higher risk of certain obstetrical complications. Vitamin D has been found to be related to preeclampsia, gestational diabetes mellitus, low birth weight, and preterm birth. The current literature supports vitamin D supplementation in pregnant women, but more high-quality data are necessary. The problem that remains is how to achieve an optimal 25-hydroxyvitamin D level. To determine the real benefits of vitamin D supplementation in pregnancy, we need high-quality trials in larger groups.

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References

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J . Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006; 36(2):361-70. DOI: 10.1002/eji.200425995. View

Eggemoen A, Jenum A, Mdala I, Knutsen K, Lagerlov P, Sletner L . Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. Br J Nutr. 2017; 117(7):985-993. DOI: 10.1017/S000711451700068X. View

Lacroix M, Battista M, Doyon M, Houde G, Menard J, Ardilouze J . Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol. 2014; 51(4):609-16. DOI: 10.1007/s00592-014-0564-4. View

Faridi K, Lupton J, Martin S, Banach M, Quispe R, Kulkarni K . Vitamin D deficiency and non-lipid biomarkers of cardiovascular risk. Arch Med Sci. 2017; 13(4):732-737. PMC: 5510501. DOI: 10.5114/aoms.2017.68237. View

Mol B, Roberts C, Thangaratinam S, Magee L, de Groot C, Hofmeyr G . Pre-eclampsia. Lancet. 2015; 387(10022):999-1011. DOI: 10.1016/S0140-6736(15)00070-7. View

Sattar N, Welsh P, Panarelli M, Forouhi N . Increasing requests for vitamin D measurement: costly, confusing, and without credibility. Lancet. 2012; 379(9811):95-6. DOI: 10.1016/S0140-6736(11)61816-3. View

Christakos S, Dhawan P, Benn B, Porta A, Hediger M, Oh G . Vitamin D: molecular mechanism of action. Ann N Y Acad Sci. 2007; 1116:340-8. DOI: 10.1196/annals.1402.070. View

Deluca H . History of the discovery of vitamin D and its active metabolites. Bonekey Rep. 2014; 3:479. PMC: 3899558. DOI: 10.1038/bonekey.2013.213. View

Gustafsson M, Romundstad P, Stafne S, Helvik A, Stunes A, Morkved S . Alterations in the vitamin D endocrine system during pregnancy: A longitudinal study of 855 healthy Norwegian women. PLoS One. 2018; 13(4):e0195041. PMC: 5895009. DOI: 10.1371/journal.pone.0195041. View

10.

Haugen M, Brantsaeter A, Trogstad L, Alexander J, Roth C, Magnus P . Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology. 2009; 20(5):720-6. DOI: 10.1097/EDE.0b013e3181a70f08. View

11.

Webb A . Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006; 92(1):17-25. DOI: 10.1016/j.pbiomolbio.2006.02.004. View

12.

Mazidi M, Michos E, Banach M . The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Arch Med Sci. 2017; 13(1):61-65. PMC: 5206371. DOI: 10.5114/aoms.2017.64714. View

13.

Chen Y, Fu L, Hao J, Yu Z, Zhu P, Wang H . Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. J Clin Endocrinol Metab. 2015; 100(5):1912-9. DOI: 10.1210/jc.2014-4407. View

14.

Azizieh F, Alyahya K, Raghupathy R . Association between levels of vitamin D and inflammatory markers in healthy women. J Inflamm Res. 2016; 9:51-7. PMC: 4854309. DOI: 10.2147/JIR.S103298. View

15.

Ensrud K, Crandall C . Osteoporosis. Ann Intern Med. 2017; 167(3):ITC17-ITC32. DOI: 10.7326/AITC201708010. View

16.

Robinson C, Wagner C, Hollis B, Baatz J, Johnson D . Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol. 2011; 204(6):556.e1-4. PMC: 3136573. DOI: 10.1016/j.ajog.2011.03.022. View

17.

Haussler M, Jurutka P, Mizwicki M, Norman A . Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011; 25(4):543-59. DOI: 10.1016/j.beem.2011.05.010. View

18.

Mateussi M, de Oliveira Cruz Latorraca C, Daou J, Martimbianco A, Riera R, Pacheco R . What do Cochrane systematic reviews say about interventions for vitamin D supplementation?. Sao Paulo Med J. 2017; 135(5):497-507. PMC: 10027242. DOI: 10.1590/1516-3180.2017.0230150817. View

19.

Schneuer F, Roberts C, Guilbert C, Simpson J, Algert C, Khambalia A . Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population. Am J Clin Nutr. 2013; 99(2):287-95. DOI: 10.3945/ajcn.113.065672. View

20.

Bodnar L, Klebanoff M, Gernand A, Platt R, Parks W, Catov J . Maternal vitamin D status and spontaneous preterm birth by placental histology in the US Collaborative Perinatal Project. Am J Epidemiol. 2013; 179(2):168-76. PMC: 3873106. DOI: 10.1093/aje/kwt237. View