Neutrophils and Neutrophil Extracellular Traps in Oral Health and Disease

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2024 Apr 30

PMID 38689085

Authors

Tae Sung Kim

Niki M Moutsopoulos

Affiliations

Soon will be listed here.

Abstract

Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis.

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References

White P, Chicca I, Cooper P, Milward M, Chapple I . Neutrophil Extracellular Traps in Periodontitis: A Web of Intrigue. J Dent Res. 2015; 95(1):26-34. DOI: 10.1177/0022034515609097. View

Silva L, Kim T, Moutsopoulos N . Neutrophils are gatekeepers of mucosal immunity. Immunol Rev. 2022; 314(1):125-141. PMC: 10496120. DOI: 10.1111/imr.13171. View

Xia J, Bolyard A, Rodger E, Stein S, Aprikyan A, Dale D . Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. Br J Haematol. 2009; 147(4):535-42. PMC: 2783282. DOI: 10.1111/j.1365-2141.2009.07888.x. View

Margraf S, Logters T, Reipen J, Altrichter J, Scholz M, Windolf J . Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock. 2008; 30(4):352-8. DOI: 10.1097/SHK.0b013e31816a6bb1. View

Iglesias-Bartolome R, Uchiyama A, Molinolo A, Abusleme L, Brooks S, Luis Callejas-Valera J . Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018; 10(451). PMC: 6598699. DOI: 10.1126/scitranslmed.aap8798. View

Celkan T . Plasminogen deficiency. J Thromb Thrombolysis. 2016; 43(1):132-138. DOI: 10.1007/s11239-016-1416-6. View

Chinwalla J, Tosi M, Bissada N . Severity of localized juvenile periodontitis as related to polymorphonuclear chemotaxis and specific microbial isolates. Periodontal Clin Investig. 1998; 20(1):6-11. View

Smith P, Munoz V, Collados L, Oyarzun A . In situ detection of matrix metalloproteinase-9 (MMP-9) in gingival epithelium in human periodontal disease. J Periodontal Res. 2004; 39(2):87-92. DOI: 10.1111/j.1600-0765.2004.00705.x. View

Bolton S, Betmouni S, Perry V . Non-nuclear histone H1 is upregulated in neurones and astrocytes in prion and Alzheimer's diseases but not in acute neurodegeneration. Neuropathol Appl Neurobiol. 1999; 25(5):425-32. DOI: 10.1046/j.1365-2990.1999.00171.x. View

10.

Drechsler M, Megens R, van Zandvoort M, Weber C, Soehnlein O . Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation. 2010; 122(18):1837-45. DOI: 10.1161/CIRCULATIONAHA.110.961714. View

11.

Emingil G, Kuula H, Sorsa T, Atilla G . Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease. J Periodontol. 2006; 77(4):664-71. DOI: 10.1902/jop.2006.050288. View

12.

Tervahartiala T, Pirila E, Ceponis A, Maisi P, Salo T, Tuter G . The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res. 2001; 79(12):1969-77. DOI: 10.1177/00220345000790120801. View

13.

Kaner D, Bernimoulin J, Kleber B, Heizmann W, Friedmann A . Gingival crevicular fluid levels of calprotectin and myeloperoxidase during therapy for generalized aggressive periodontitis. J Periodontal Res. 2006; 41(2):132-9. DOI: 10.1111/j.1600-0765.2005.00849.x. View

14.

Keshari R, Jyoti A, Kumar S, Dubey M, Verma A, Srinag B . Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential. Cytometry A. 2011; 81(3):238-47. DOI: 10.1002/cyto.a.21178. View

15.

Li Y, Liu B, Fukudome E, Lu J, Chong W, Jin G . Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock. Surgery. 2011; 150(3):442-51. PMC: 3170094. DOI: 10.1016/j.surg.2011.07.003. View

16.

Introne W, Boissy R, Gahl W . Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome. Mol Genet Metab. 1999; 68(2):283-303. DOI: 10.1006/mgme.1999.2927. View

17.

Chapple I, Hirschfeld J, Kantarci A, Wilensky A, Shapira L . The role of the host-Neutrophil biology. Periodontol 2000. 2023; . DOI: 10.1111/prd.12490. View

18.

Allam R, Scherbaum C, Darisipudi M, Mulay S, Hagele H, Lichtnekert J . Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol. 2012; 23(8):1375-88. PMC: 3402284. DOI: 10.1681/ASN.2011111077. View

19.

ONeil L, Oliveira C, Sandoval-Heglund D, Barrera-Vargas A, Merayo-Chalico J, Aguirre-Aguilar E . Anti-Carbamylated LL37 Antibodies Promote Pathogenic Bone Resorption in Rheumatoid Arthritis. Front Immunol. 2021; 12:715997. PMC: 8477029. DOI: 10.3389/fimmu.2021.715997. View

20.

Kubota T, Nomura T, Takahashi T, Hara K . Expression of mRNA for matrix metalloproteinases and tissue inhibitors of metalloproteinases in periodontitis-affected human gingival tissue. Arch Oral Biol. 1996; 41(3):253-62. DOI: 10.1016/0003-9969(95)00126-3. View