One-Pot Syntesis of 3-Functionalized 4-Hydroxycoumarin Under Catalyst-Free Conditions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Jan 25

PMID 29361771

Citations 2

Authors

Yang Gao

Guo-Ning Zhang

Juxian Wang

Xiaoguang Bai

Yiliang Li

Yucheng Wang

Affiliations

Soon will be listed here.

Abstract

A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.

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