N,N-DIIsopropyl-N-phosphonyl Imines Lead to Efficient Asymmetric Synthesis of Aziridine-2-carboxylic Esters

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2013 Apr 9

PMID 23563304

Citations 6

Authors

Padmanabha V Kattamuri

Yiwen Xiong

Yi Pan

Guigen Li

Affiliations

Soon will be listed here.

Abstract

Highly diastereoselective asymmetric synthesis of chiral aziridine-2-carboxylic esters is reported for 20 examples with good yields (51-87%) and excellent diastereoselectivities (>99:1 dr for most cases). The modified N-phosphonyl imines have proven to be superior to previous imine auxiliaries for the aza Darzens reaction by using a secondary isopropyl group to replace the primary benzyl group for N,N-diamino protection. In the meanwhile, a special operation by slowly adding the pre-cooled imine solution at -78 °C into the preformed β-bromo lithium enolate mixture at this temperature in the presence of 4 Å molecular sieves was found to be crucial in terms of yields and diastereoselectivity. The present method can provide an easy and general access to β-hydroxy α-amino acids and other important amino building blocks.

Citing Articles

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