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Synthesis, Anticoagulant and PIVKA-II Induced by New 4-hydroxycoumarin Derivatives

Overview
Journal Bioorg Med Chem
Specialties Biochemistry
Chemistry
Date 2010 May 4
PMID 20435480
Citations 22
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Abstract

The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.

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