Immunoenhancement of Edible Fungal Polysaccharides (Lentinan, Tremellan, and Pachymaran) on Cyclophosphamide-Induced Immunosuppression in Mouse Model

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Jan 24

PMID 29358974

Citations 11

Authors

Qian Zhang

Renhuai Cong

Minghua Hu

Yanhong Zhu

Xiangliang Yang

Affiliations

Soon will be listed here.

Abstract

Fungal polysaccharides display a variety of important biological activities, including anti-inflammatory, antitumor, and immune-stimulating activities. The aim of present study was to investigate the immunomodulatory effect of fungal polysaccharides on cyclophosphamide-induced immunosuppression in mice. Mice were pretreated orally with lentinan, tremellan, pachymaran, or a mixture of the three, respectively. The results showed that pretreatments with polysaccharides significantly increased the thymus index in cyclophosphamide-induced immunosuppression mice. The level of the cytokine IL-10 in sera of cyclophosphamide-induced mice was decreased after pretreatments of polysaccharides. Flow cytometry results showed that pretreatments with polysaccharides enhanced the phagocytosis of peritoneal macrophages in mice. The increased levels of serum antibody IgG and IgM were observed in the groups pretreated with polysaccharides. Our work demonstrated that the treatment of polysaccharides elicited strong immune activity and a protective effect against cyclophosphamide-induced immunosuppression.

Citing Articles

Extraction and Identification of Polysaccharide from and Its Effect on Immunosuppression and Intestinal Barrier Injury Induced by Cyclophosphamide.

Jin X, Wu Z, Chen H, Liu W, Gu F, Li J Int J Mol Sci. 2024; 25(22).

PMID: 39596497 PMC: 11594469. DOI: 10.3390/ijms252212432.

Effect of Flavonols of Fruits on Morphofunctional State of Immunocompetent Organs of Rats under Cyclophosphamide-Induced Immunosuppression.

Bushmeleva K, Vyshtakalyuk A, Terenzhev D, Belov T, Nikitin E, Zobov V Biomolecules. 2024; 14(5).

PMID: 38785985 PMC: 11117470. DOI: 10.3390/biom14050578.

The Effects of Lentinan on the Hematological and Immune Indices of Dairy Cows.

Tan L, Fan C, Wang D, Li X, Wang M, Zhuo Z Animals (Basel). 2024; 14(9).

PMID: 38731317 PMC: 11083140. DOI: 10.3390/ani14091314.

Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde.

Zhang Z, Yang Y, Hu C, Zhang Z Sci Rep. 2023; 13(1):17465.

PMID: 37838763 PMC: 10576801. DOI: 10.1038/s41598-023-44788-y.

Protective Effect of Polysaccharide against Cyclophosphamide-Induced Immunosuppression in BALB/c Mice.

Xie A, Wan H, Feng L, Yang B, Wan Y Foods. 2023; 12(9).

PMID: 37174447 PMC: 10178248. DOI: 10.3390/foods12091910.

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