Effect of Flavonols of Fruits on Morphofunctional State of Immunocompetent Organs of Rats Under Cyclophosphamide-Induced Immunosuppression

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 May 24

PMID 38785985

Authors

Kseniya Bushmeleva

Alexandra Vyshtakalyuk

Dmitriy Terenzhev

Timur Belov

Evgeniy Nikitin

Vladimir Zobov

Affiliations

Soon will be listed here.

Abstract

berries contain many compounds with potential benefits for human health. The food flavonoids quercetin and rutin, found in significant amounts in the fruits of , are known to have favourable effects on animal and human organisms. However, data on the effect of flavonols isolated from black chokeberry on immune functions during immunosuppression are not available in the literature. Thus, the aim of this study was to evaluate the effect of flavonol fraction isolated from fruits, in comparison with pure quercetin and rutin substances, on the dysfunctional state of rat thymus and spleen in immunodeficiency. The study was performed on Wistar rats. The animals were orally administered solutions of the investigated substances for 7 days: water, a mixture of quercetin and rutin and flavonol fraction of . For induction of immunosuppression, the animals were injected once intraperitoneally with cyclophosphamide. Substance administration was then continued for another 7 days. The results showed that under the influence of flavonols, there was a decrease in cyclophosphamide-mediated reaction of lipid peroxidation enhancement and stimulation of proliferation of lymphocytes of thymus and spleen in rats. At that, the effect of the flavonol fraction of aronia was more pronounced.

Citing Articles

Immunomodulatory effects of CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice.

Ma W, Sun H, Lian L, Guo L, Wang Y, Huang L Front Immunol. 2025; 16:1513531.

PMID: 39931067 PMC: 11807972. DOI: 10.3389/fimmu.2025.1513531.

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