INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2018 Jan 19

PMID 29346761

Citations 17

Authors

Graeme J Gowans

Alicia N Schep

Ka Man Wong

Devin A King

William J Greenleaf

Ashby J Morrison

Affiliations

Soon will be listed here.

Abstract

Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression. Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression. Collectively, these results reveal that the INO80 complex mediates metabolic signaling to chromatin to restrict proliferation to metabolically optimal states.

Citing Articles

Uncharacterized yeast gene , an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via - and -dependent mechanisms.

Alfatah M, Lim J, Zhang Y, Naaz A, Cheng T, Yogasundaram S Elife. 2024; 12.

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INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation.

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Genome-Wide Analysis of Yeast Metabolic Cycle through Metabolic Network Models Reveals Superiority of Integrated ATAC-seq Data over RNA-seq Data.

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