A Randomized Controlled Clinical Study of Periodontal Tissue Regeneration Using an Extracellular Matrix-based Resorbable Membrane in Combination with a Collagenated Bovine Bone Graft in Intrabony Defects

Overview

Journal J Periodontal Implant Sci

Specialty Dentistry

Date 2018 Jan 16

PMID 29333322

Authors

Sulhee Kim

Hyeyoon Chang

Jin Wook Hwang

Sungtae Kim

Ki-Tae Koo

Tae-Il Kim

Yang-Jo Seol

Yong-Moo Lee

Young Ku

Jong-Ho Lee

In-Chul Rhyu

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically.

Methods: Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants. A novel extracellular matrix membrane (NEM) and a widely-used membrane (WEM) were randomly applied to the test group and the control group, respectively. Cone-beam computed tomography images were obtained on the day of surgery and 6 months after the procedure. Alginate impressions were taken and plaster models were made 1 week and 6 months postoperatively.

Results: The quantity of bone tissue, the dimensional changes of the surgically treated intrabony defects, and the changes in width and height below the grafted bone substitutes showed no significant difference between the test and control groups at the 6-month examination.

Conclusions: The use of NEM for periodontal regeneration with a collagenated bovine bone graft showed similar clinical and radiologic results to those obtained using WEM.

References

Nevins M, Camelo M, Rebaudi A, Lynch S, Nevins M . Three-dimensional micro-computed tomographic evaluation of periodontal regeneration: a human report of intrabony defects treated with Bio-Oss collagen. Int J Periodontics Restorative Dent. 2005; 25(4):365-73. View

Sculean A, Stavropoulos A, Windisch P, Keglevich T, Karring T, Gera I . Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration. Clin Oral Investig. 2004; 8(2):70-4. DOI: 10.1007/s00784-004-0254-7. View

Grimard B, Hoidal M, Mills M, Mellonig J, Nummikoski P, Mealey B . Comparison of clinical, periapical radiograph, and cone-beam volume tomography measurement techniques for assessing bone level changes following regenerative periodontal therapy. J Periodontol. 2009; 80(1):48-55. DOI: 10.1902/jop.2009.080289. View

Nevins M, Camelo M, Lynch S, Schenk R, Nevins M . Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen: a human histologic report. Int J Periodontics Restorative Dent. 2003; 23(1):9-17. View

Slotte C, Lindfors N, Nannmark U . Surgical reconstruction of peri-implant bone defects with prehydrated and collagenated porcine bone and collagen barriers: case presentations. Clin Implant Dent Relat Res. 2011; 15(5):714-23. DOI: 10.1111/j.1708-8208.2011.00402.x. View

Jimenez Garcia J, Berghezan S, Carames J, Dard M, Marques D . Effect of cross-linked vs non-cross-linked collagen membranes on bone: A systematic review. J Periodontal Res. 2017; 52(6):955-964. DOI: 10.1111/jre.12470. View

Kiany F, Moloudi F . Amnion membrane as a novel barrier in the treatment of intrabony defects: a controlled clinical trial. Int J Oral Maxillofac Implants. 2015; 30(3):639-47. DOI: 10.11607/jomi.3590. View

Sheikh Z, Hamdan N, Ikeda Y, Grynpas M, Ganss B, Glogauer M . Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review. Biomater Res. 2017; 21:9. PMC: 5460509. DOI: 10.1186/s40824-017-0095-5. View

Ortolani E, Quadrini F, Bellisario D, Santo L, Polimeni A, Santarsiero A . Mechanical qualification of collagen membranes used in dentistry. Ann Ist Super Sanita. 2015; 51(3):229-35. DOI: 10.4415/ANN_15_03_11. View

10.

Paolantonio M . Combined periodontal regenerative technique in human intrabony defects by collagen membranes and anorganic bovine bone. A controlled clinical study. J Periodontol. 2002; 73(2):158-66. DOI: 10.1902/jop.2002.73.2.158. View

11.

Becker J, Al-Nawas B, Klein M, Schliephake H, Terheyden H, Schwarz F . Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants: a prospective, randomized-controlled double-blinded clinical multicenter study. Clin Oral Implants Res. 2009; 20(7):742-9. DOI: 10.1111/j.1600-0501.2008.01689.x. View

12.

Schwarz F, Sahm N, Mihatovic I, Golubovic V, Becker J . Surgical therapy of advanced ligature-induced peri-implantitis defects: cone-beam computed tomographic and histological analysis. J Clin Periodontol. 2011; 38(10):939-49. DOI: 10.1111/j.1600-051X.2011.01739.x. View

13.

Needleman I, Worthington H, Giedrys-Leeper E, Tucker R . Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev. 2006; (2):CD001724. DOI: 10.1002/14651858.CD001724.pub2. View

14.

Needleman I, Tucker R, Giedrys-Leeper E, Worthington H . A systematic review of guided tissue regeneration for periodontal infrabony defects. J Periodontal Res. 2002; 37(5):380-8. DOI: 10.1034/j.1600-0765.2002.01369.x. View

15.

Chang H, Kim S, Hwang J, Kim S, Koo K, Kim T . Comparative, randomized, double-blind clinical study of alveolar ridge preservation using an extracellular matrix-based dental resorbable membrane in the extraction socket. J Periodontal Implant Sci. 2017; 47(3):165-173. PMC: 5494311. DOI: 10.5051/jpis.2017.47.3.165. View

16.

Reynolds M, Aichelmann-Reidy M, Branch-Mays G, Gunsolley J . The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol. 2004; 8(1):227-65. DOI: 10.1902/annals.2003.8.1.227. View

17.

Tonetti M, Fourmousis I, Suvan J, Cortellini P, Bragger U, Lang N . Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. J Clin Periodontol. 2004; 31(12):1092-8. DOI: 10.1111/j.1600-051X.2004.00615.x. View

18.

Park J, Yang C, Kim Y, Kim M, Lee J, Choi S . Space maintenance using crosslinked collagenated porcine bone grafted without a barrier membrane in one-wall intrabony defects. J Biomed Mater Res B Appl Biomater. 2014; 102(7):1454-61. DOI: 10.1002/jbm.b.33124. View

19.

Wikesjo U, Lim W, Thomson R, Hardwick W . Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR?. J Clin Periodontol. 2003; 30(7):655-64. DOI: 10.1034/j.1600-051x.2003.00362.x. View

20.

Hwang J, Kim S, Kim S, Lee J . Effect of Extracellular Matrix Membrane on Bone Formation in a Rabbit Tibial Defect Model. Biomed Res Int. 2016; 2016:6715295. PMC: 4800078. DOI: 10.1155/2016/6715295. View