Identification of a Temperature-sensitive Mutation in the HtpR (rpoH) Gene of Escherichia Coli K-12

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1985 Nov 1

PMID 2932429

Citations 1

Authors

C Waghorne

C R Fuerst

Affiliations

Soon will be listed here.

Abstract

A new mutation in the htpR (rpoH) gene of Escherichia coli K-12 was identified. The mutation resulted in a temperature-sensitive phenotype in terms of cell growth and bacteriophage lambda development. As in the case of the classical htpR tsn-165 mutation, synthesis of heat shock polypeptides was not induced in strains carrying the mutation described here.

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A sigma32 mutant with a single amino acid change in the highly conserved region 2.2 exhibits reduced core RNA polymerase affinity.

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PMID: 9144163 PMC: 24604. DOI: 10.1073/pnas.94.10.4907.

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