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Modeling Psychiatric Disorders Using Patient Stem Cell-derived Neurons: a Way Forward

Overview
Journal Genome Med
Publisher Biomed Central
Specialty Genetics
Date 2018 Jan 6
PMID 29301565
Citations 18
Authors
Krishna C Vadodaria
Debha N Amatya
Maria C Marchetto
Fred H Gage
Affiliations
Soon will be listed here.
Abstract

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

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