Annexin A2 is an Independent Prognostic Biomarker for Evaluating the Malignant Progression of Laryngeal Cancer

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2017 Dec 30

PMID 29285166

Citations 17

Authors

Shi Luo

Chubo Xie

Ping Wu

Jian He

Yaoyun Tang

Jing Xu

Suping Zhao

Affiliations

Soon will be listed here.

Abstract

Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

Citing Articles

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