Human Colorectal Cancer Progression Correlates with LOX-induced ECM Stiffening

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2017 Dec 7

PMID 29209148

Citations 43

Authors

Bo Wei

Xueling Zhou

Chenghua Liang

Xiaoming Zheng

Purun Lei

Jiafeng Fang

Xiaoyan Han

Lijing Wang

Cuiling Qi

Hongbo Wei

Affiliations

Soon will be listed here.

Abstract

Some solid tumors are characterized by extracellular matrix (ECM) remodeling and stiffening, which is related to solid tumor progression and aggression. However, the relationship between ECM stiffness and colorectal cancer (CRC) remains unclear. In this study, we investigated the relevance of ECM stiffness to clinicopathologic features using human CRC tissue microarrays. The results demonstrate that the expression of ECM components in CRC tissues is closely correlated with CRC progression and poor prognosis, which indicates that ECM stiffness may be associated with CRC development. We further studied lysyl oxidase (LOX) expression in CRC tissue and demonstrated that LOX expression is closely correlated with CRC progression. Previous studies showed that P-selectin-mediated platelet accumulation in CRC tissue may up-regulate LOX expression. Our findings indicate that P-selectin-mediated platelet aggregation may up-regulate LOX expression and enhance the remodeling and stiffening of the tumor ECM, which may promote the progression of colorectal cancer. Therefore, LOX may be a potential effective therapeutic target to treat colorectal cancer.

Citing Articles

Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer.

Zhang X, Al-Danakh A, Zhu X, Feng D, Yang L, Wu H Bioeng Transl Med. 2025; 10(1):e10698.

PMID: 39801760 PMC: 11711218. DOI: 10.1002/btm2.10698.

Lysyl oxidase inhibitors in colorectal cancer progression.

Liu M, Wang J, Liu M Transl Oncol. 2024; 52():102233.

PMID: 39675250 PMC: 11713484. DOI: 10.1016/j.tranon.2024.102233.

CAF-induced physical constraints controlling T cell state and localization in solid tumours.

Arpinati L, Carradori G, Scherz-Shouval R Nat Rev Cancer. 2024; 24(10):676-693.

PMID: 39251836 DOI: 10.1038/s41568-024-00740-4.

Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial-Stromal Interplay in Cancer Development.

Karunasagara S, Taghizadeh A, Kim S, Kim S, Kim Y, Taghizadeh M Adv Sci (Weinh). 2024; 11(35):e2400063.

PMID: 38976559 PMC: 11425211. DOI: 10.1002/advs.202400063.

Maintenance of genome integrity under physical constraints.

Soutoglou E, Oberdoerffer P Chromosoma. 2024; 133(1):1-3.

PMID: 38355990 DOI: 10.1007/s00412-024-00816-y.

References

Michor F, Weaver V . Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014; 16(4):301-2. PMC: 4180082. DOI: 10.1038/ncb2942. View

Yamauchi M, Sricholpech M . Lysine post-translational modifications of collagen. Essays Biochem. 2012; 52:113-33. PMC: 3499978. DOI: 10.1042/bse0520113. View

Xiao Q, Ge G . Lysyl oxidase, extracellular matrix remodeling and cancer metastasis. Cancer Microenviron. 2012; 5(3):261-73. PMC: 3460045. DOI: 10.1007/s12307-012-0105-z. View

McAllister S, Weinberg R . Tumor-host interactions: a far-reaching relationship. J Clin Oncol. 2010; 28(26):4022-8. DOI: 10.1200/JCO.2010.28.4257. View

Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C . Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb). 2015; 7(10):1120-34. PMC: 4593730. DOI: 10.1039/c5ib00040h. View

Huang R, Huang D, Dai W, Yang F . Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer. Mol Cell Biochem. 2015; 404(1-2):251-7. DOI: 10.1007/s11010-015-2384-4. View

Samani A, Zubovits J, Plewes D . Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples. Phys Med Biol. 2007; 52(6):1565-76. DOI: 10.1088/0031-9155/52/6/002. View

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

Paszek M, Weaver V . The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia. 2005; 9(4):325-42. DOI: 10.1007/s10911-004-1404-x. View

10.

Eheman C, Henley S, Ballard-Barbash R, Jacobs E, Schymura M, Noone A . Annual Report to the Nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity. Cancer. 2012; 118(9):2338-66. PMC: 4586174. DOI: 10.1002/cncr.27514. View

11.

Butcher D, Alliston T, Weaver V . A tense situation: forcing tumour progression. Nat Rev Cancer. 2009; 9(2):108-22. PMC: 2649117. DOI: 10.1038/nrc2544. View

12.

Samani A, Bishop J, Luginbuhl C, Plewes D . Measuring the elastic modulus of ex vivo small tissue samples. Phys Med Biol. 2003; 48(14):2183-98. DOI: 10.1088/0031-9155/48/14/310. View

13.

Chun T, Hotary K, Sabeh F, Saltiel A, Allen E, Weiss S . A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell. 2006; 125(3):577-91. DOI: 10.1016/j.cell.2006.02.050. View

14.

Santhanam A, Baker A, Hegamyer G, Kirschmann D, Colburn N . Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. Oncogene. 2010; 29(27):3921-32. PMC: 3419530. DOI: 10.1038/onc.2010.158. View

15.

Chen W, Zheng R, Baade P, Zhang S, Zeng H, Bray F . Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2):115-32. DOI: 10.3322/caac.21338. View

16.

Qi C, Wei B, Zhou W, Yang Y, Li B, Guo S . P-selectin-mediated platelet adhesion promotes tumor growth. Oncotarget. 2015; 6(9):6584-96. PMC: 4466636. DOI: 10.18632/oncotarget.3164. View

17.

Qi C, Li B, Guo S, Wei B, Shao C, Li J . P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in Apc(Min/+) Mice. Int J Biol Sci. 2015; 11(6):679-87. PMC: 4440258. DOI: 10.7150/ijbs.11589. View

18.

Wozniak M, Desai R, Solski P, Der C, Keely P . ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol. 2003; 163(3):583-95. PMC: 2173660. DOI: 10.1083/jcb.200305010. View

19.

Berrino F, De Angelis R, Sant M, Rosso S, Bielska-Lasota M, Lasota M . Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol. 2007; 8(9):773-83. DOI: 10.1016/S1470-2045(07)70245-0. View

20.

Peyrol S, Raccurt M, Gerard F, Gleyzal C, Grimaud J, Sommer P . Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma. Am J Pathol. 1997; 150(2):497-507. PMC: 1858268. View