Understanding Tissue Context Influences on Intratumour Heterogeneity

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2014 Apr 3

PMID 24691256

Citations 13

Authors

Franziska Michor

Valerie M Weaver

Affiliations

Soon will be listed here.

Abstract

Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy.

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