Activation of Vibrio Cholerae Quorum Sensing Promotes Survival of an Arthropod Host

Overview

Journal Nat Microbiol

Specialties Microbiology
Parasitology

Date 2017 Nov 29

PMID 29180725

Citations 31

Authors

Layla Kamareddine

Adam C N Wong

Audrey S Vanhove

Saiyu Hang

Alexandra E Purdy

Katharine Kierek-Pearson

John M Asara

Afsar Ali

J Glenn Morris Jr

Paula I Watnick

Affiliations

Soon will be listed here.

Abstract

Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aquatic environment. Attachment to these surfaces is regulated by the bacterial quorum-sensing signal transduction cascade, which allows bacteria to assess the density of microbial neighbours. Intestinal colonization with V. cholerae results in expenditure of host lipid stores in the model arthropod Drosophila melanogaster. Here we report that activation of quorum sensing in the Drosophila intestine retards this process by repressing V. cholerae succinate uptake. Increased host access to intestinal succinate mitigates infection-induced lipid wasting to extend survival of V. cholerae-infected flies. Therefore, quorum sensing promotes a more favourable interaction between V. cholerae and an arthropod host by reducing the nutritional burden of intestinal colonization.

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