Transcriptomics-driven Lipidomics (TDL) Identifies the Microbiome-regulated Targets of Ileal Lipid Metabolism

Overview

Journal NPJ Syst Biol Appl

Specialty Biology

Date 2017 Nov 16

PMID 29138692

Citations 8

Authors

Anirikh Chakrabarti

Mathieu Membrez

Delphine Morin-Rivron

Jay Siddharth

Chieh Jason Chou

Hugues Henry

Stephen Bruce

Sylviane Metairon

Frederic Raymond

Bertrand Betrisey

Carole Loyer

Scott J Parkinson

Mojgan Masoodi

Affiliations

Soon will be listed here.

Abstract

The gut microbiome and lipid metabolism are both recognized as essential components in the maintenance of metabolic health. The mechanisms involved are multifactorial and (especially for microbiome) poorly defined. A strategic approach to investigate the complexity of the microbial influence on lipid metabolism would facilitate determination of relevant molecular mechanisms for microbiome-targeted therapeutics. is associated with obesity and metabolic syndrome and we used this association in conjunction with gnotobiotic models to investigate the impact of on lipid metabolism. To address the complexities of the integration of the microbiome and lipid metabolism, we developed transcriptomics-driven lipidomics (TDL) to predict the impact of colonization on lipid metabolism and established mediators of inflammation and insulin resistance including arachidonic acid metabolism, alterations in bile acids and dietary lipid absorption. A microbiome-related therapeutic approach targeting these mechanisms may therefore provide a therapeutic avenue supporting maintenance of metabolic health.

Citing Articles

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective.

Aziz T, Khan A, Tzora A, Voidarou C, Skoufos I Nutrients. 2023; 15(13).

PMID: 37447285 PMC: 10343808. DOI: 10.3390/nu15132956.

Impact of Dietary Arachidonic Acid on Gut Microbiota Composition and Gut-Brain Axis in Male BALB/C Mice.

Pinchaud K, Hafeez Z, Auger S, Chatel J, Chadi S, Langella P Nutrients. 2022; 14(24).

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Dysregulation of Lipid and Glucose Homeostasis in Hepatocyte-Specific SLC25A34 Knockout Mice.

Roy N, Alencastro F, Roseman B, Wilson S, Delgado E, May M Am J Pathol. 2022; 192(9):1259-1281.

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Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response.

Otake-Kasamoto Y, Kayama H, Kishikawa T, Shinzaki S, Tashiro T, Amano T J Exp Med. 2022; 219(7).

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Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.

Jouffe C, Weger B, Martin E, Atger F, Weger M, Gobet C Proc Natl Acad Sci U S A. 2022; 119(10):e2200083119.

PMID: 35238641 PMC: 8916004. DOI: 10.1073/pnas.2200083119.

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