The Gestational Power of Mast Cells in the Injured Tissue

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2017 Nov 5

PMID 29101413

Citations 1

Authors

Maria-Angeles Aller

Natalia Arias

Vicente Martinez

Patri Vergara

Jaime Arias

Affiliations

Soon will be listed here.

Abstract

The inflammatory response expressed after wound healing would be the recapitulation of systemic extra-embryonic functions, which would focus on the interstitium of the injured tissue. In the injured tissue, mast cells, provided for a great functional heterogeneity, could play the leading role in the re-expression of extra-embryonic functions, i.e., coelomic-amniotic and trophoblastic-vitelline. Moreover, mast cells would favor the production of a gastrulation-like process, which in certain tissues and organs would induce the regeneration of the injured tissue. Therefore, the engraftment of mesenchymal stem cells and mast cells, both with an extra-embryonic regenerative phenotype, would achieve a blastema, from the repaired and regenerated injured tissue, rather than by fibrosis, which is commonly made through wound-healing.

Citing Articles

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases - Stevens-Johnson syndrome and toxic epidermal necrolysis treatment.

Klama-Baryla A, Rojczyk E, Kitala D, Labus W, Smetek W, Wilemska-Kucharzewska K Int Wound J. 2020; 17(2):491-507.

PMID: 31943788 PMC: 7949443. DOI: 10.1111/iwj.13305.

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