Human Umbilical Cord Blood-derived Mast Cells: a Unique Model for the Study of Neuro-immuno-endocrine Interactions

Overview

Journal Stem Cell Rev

Specialty Cell Biology

Date 2007 Jan 24

PMID 17237553

Citations 6

Authors

T C Theoharides

D Kempuraj

M Tagen

M Vasiadi

C L Cetrulo

Affiliations

Soon will be listed here.

Abstract

Findings obtained using animal models have often failed to reflect the processes involved in human disease. Moreover, human cultured cells do not necessarily function as their actual tissue counterparts. Therefore, there is great demand for sources of human progenitor cells that may be directed to acquire specific tissue characteristics and be available in sufficient quantities to carry out functional and pharmacological studies. Acase in point is the mast cell, well known for its involvement in allergic reactions, but also implicated in inflammatory diseases. Mast cells can be activated by allergens, anaphylatoxins, immunoglobulin-free light chains, superantigens, neuropeptides, and cytokines, leading to selective release of mediators. These could be involved in many inflammatory diseases, such as asthma and atopic dermatitis, which worsen by stress, through activation by local release of corticotropin-releasing hormone or related peptides. Umbilical cord blood and cord matrix-derived mast cell progenitors can be separated magnetically and grown in the presence of stem cell factor, interleukin-6, interleukin-4, and other cytokines to yield distinct mast cell populations. The recent use of live cell array, with its ability to study such interactions rapidly at the single-cell level, provides unique new opportunities for fast output screening of mast cell triggers and inhibitors.

Citing Articles

The gestational power of mast cells in the injured tissue.

Aller M, Arias N, Martinez V, Vergara P, Arias J Inflamm Res. 2017; 67(2):111-116.

PMID: 29101413 DOI: 10.1007/s00011-017-1108-5.

Generation of mast cells from mouse fetus: analysis of differentiation and functionality, and transcriptome profiling using next generation sequencer.

Fukuishi N, Igawa Y, Kunimi T, Hamano H, Toyota M, Takahashi H PLoS One. 2013; 8(4):e60837.

PMID: 23573287 PMC: 3616098. DOI: 10.1371/journal.pone.0060837.

Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.

Rudich N, Ravid K, Sagi-Eisenberg R Front Immunol. 2012; 3:134.

PMID: 22675325 PMC: 3366457. DOI: 10.3389/fimmu.2012.00134.

Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates.

Suarez A, Feramisco J, Koo J, Steinhoff M Acta Derm Venereol. 2011; 92(1):7-15.

PMID: 22101513 PMC: 3704139. DOI: 10.2340/00015555-1188.

IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.

Hua X, Chason K, Patel J, Naselsky W, Tilley S PLoS One. 2011; 6(9):e24947.

PMID: 21966389 PMC: 3180290. DOI: 10.1371/journal.pone.0024947.

References

Boesiger J, Tsai M, Maurer M, Yamaguchi M, Brown L, Claffey K . Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J Exp Med. 1998; 188(6):1135-45. PMC: 2212544. DOI: 10.1084/jem.188.6.1135. View

Theoharides T, Donelan J, Kandere-Grzybowska K, Konstantinidou A . The role of mast cells in migraine pathophysiology. Brain Res Brain Res Rev. 2005; 49(1):65-76. DOI: 10.1016/j.brainresrev.2004.11.006. View

Dimitriadou V, Buzzi M, Moskowitz M, Theoharides T . Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience. 1991; 44(1):97-112. DOI: 10.1016/0306-4522(91)90253-k. View

Cao J, Cetrulo C, Theoharides T . Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway. Mol Pharmacol. 2005; 69(3):998-1006. DOI: 10.1124/mol.105.019539. View

. Self-reported increase in asthma severity after the September 11 attacks on the World Trade Center--Manhattaan, New York, 2001. MMWR Morb Mortal Wkly Rep. 2002; 51(35):781-4. View

Wooley D . Mast cells in the rheumatoid lesion--ringleaders or innocent bystanders?. Ann Rheum Dis. 1995; 54(7):533-4. PMC: 1009925. DOI: 10.1136/ard.54.7.533. View

Varadaradjalou S, Feger F, Thieblemont N, Ben Hamouda N, Pleau J, Dy M . Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur J Immunol. 2003; 33(4):899-906. DOI: 10.1002/eji.200323830. View

Aderem A, Ulevitch R . Toll-like receptors in the induction of the innate immune response. Nature. 2000; 406(6797):782-7. DOI: 10.1038/35021228. View

Goetzl E, Chernov T, Renold F, Payan D . Neuropeptide regulation of the expression of immediate hypersensitivity. J Immunol. 1985; 135(2 Suppl):802s-805s. View

10.

Smith A, Nicholson K . Psychosocial factors, respiratory viruses and exacerbation of asthma. Psychoneuroendocrinology. 2001; 26(4):411-20. PMC: 7125531. DOI: 10.1016/s0306-4530(00)00063-9. View

11.

Kilpelainen M, Koskenvuo M, Helenius H, Terho E . Stressful life events promote the manifestation of asthma and atopic diseases. Clin Exp Allergy. 2002; 32(2):256-63. DOI: 10.1046/j.1365-2222.2002.01282.x. View

12.

Gordon D, Rifkind B . High-density lipoprotein--the clinical implications of recent studies. N Engl J Med. 1989; 321(19):1311-6. DOI: 10.1056/NEJM198911093211907. View

13.

Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen P . Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery. Circulation. 1999; 99(3):361-9. DOI: 10.1161/01.cir.99.3.361. View

14.

Carraway R, Cochrane D, Boucher W, Mitra S . Structures of histamine-releasing peptides formed by the action of acid proteases on mammalian albumin(s). J Immunol. 1989; 143(5):1680-4. View

15.

Theoharides T, Singh L, Boucher W, Pang X, Letourneau R, Webster E . Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology. 1998; 139(1):403-13. DOI: 10.1210/endo.139.1.5660. View

16.

Kandere-Grzybowska K, Gheorghe D, Priller J, Esposito P, Huang M, Gerard N . Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Brain Res. 2003; 980(2):213-20. DOI: 10.1016/s0006-8993(03)02975-5. View

17.

Wang H, Hung S, Peng S, Huang C, Wei H, Guo Y . Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 2004; 22(7):1330-7. DOI: 10.1634/stemcells.2004-0013. View

18.

Church M, Clough G . Human skin mast cells: in vitro and in vivo studies. Ann Allergy Asthma Immunol. 1999; 83(5):471-5. DOI: 10.1016/S1081-1206(10)62853-0. View

19.

Kraeuter Kops S, Theoharides T, Cronin C, Kashgarian M, Askenase P . Ultrastructural characteristics of rat peritoneal mast cells undergoing differential release of serotonin without histamine and without degranulation. Cell Tissue Res. 1990; 262(3):415-24. DOI: 10.1007/BF00305238. View

20.

Slominski A, Wortsman J . Neuroendocrinology of the skin. Endocr Rev. 2000; 21(5):457-87. DOI: 10.1210/edrv.21.5.0410. View