EIF3: a Factor for Human Health and Disease

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2017 Nov 4

PMID 29099306

Citations 46

Authors

Andreia Gomes-Duarte

Rafaela Lacerda

Juliane Menezes

Luisa Romao

Affiliations

Soon will be listed here.

Abstract

The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.

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