Current Advances of Long Non-coding RNA Highly Upregulated in Liver Cancer in Human Tumors

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2017 Oct 14

PMID 29026319

Citations 18

Authors

Zhonghua Ma

Hesuyuan Huang

Yetao Xu

Xuezhi He

Jirong Wang

Bingqing Hui

Hao Ji

Jing Zhou

Keming Wang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs (ncRNAs) >200 nucleotides in length that govern diverse biological processes. Recent evidence suggests that lncRNAs are involved in cancer cell proliferation, apoptosis, invasion, migration, and metastasis. Dysregulation of lncRNAs has been observed in various tumors, and lncRNAs act as oncogenes or tumor suppressors in these malignancies. It has been revealed that lncRNA highly upregulated in liver cancer (HULC) is tightly correlated with a number of cancers such as hepatocellular carcinoma, gastric cancer, colorectal cancer, osteosarcoma, and diffuse large B-cell lymphoma. Depletion of HULC suppressed cancer cell proliferation, migration, and invasion and induced apoptosis. Additionally, HULC may function as a diagnostic biomarker and prognostic indicator for some tumors. In this review, we summarize the current knowledge of the role of HULC in cancer progression and the clinical management of human cancers.

Citing Articles

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References

Liu J, Liu S, Wang J, Zhu W, Hua Y, Sun W . Telangiectatic osteosarcoma: a review of literature. Onco Targets Ther. 2013; 6:593-602. PMC: 3671797. DOI: 10.2147/OTT.S41351. View

Yu X, Li Z, Yu J, Chan M, Wu W . MicroRNAs predict and modulate responses to chemotherapy in colorectal cancer. Cell Prolif. 2015; 48(5):503-10. PMC: 6496401. DOI: 10.1111/cpr.12202. View

Liu Y, Pan S, Liu L, Zhai X, Liu J, Wen J . A genetic variant in long non-coding RNA HULC contributes to risk of HBV-related hepatocellular carcinoma in a Chinese population. PLoS One. 2012; 7(4):e35145. PMC: 3320879. DOI: 10.1371/journal.pone.0035145. View

Panzitt K, Tschernatsch M, Guelly C, Moustafa T, Stradner M, Strohmaier H . Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 2007; 132(1):330-42. DOI: 10.1053/j.gastro.2006.08.026. View

Peng W, Wu J, Feng J . Long noncoding RNA HULC predicts poor clinical outcome and represents pro-oncogenic activity in diffuse large B-cell lymphoma. Biomed Pharmacother. 2016; 79:188-93. DOI: 10.1016/j.biopha.2016.02.032. View

Liu C, Li S, Dai X, Ma J, Wan J, Jiang H . PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex. Nucleic Acids Res. 2015; 43(13):6270-84. PMC: 4513857. DOI: 10.1093/nar/gkv574. View

Maluccio M, Covey A . Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 2012; 62(6):394-9. DOI: 10.3322/caac.21161. View

Fung K, Nice E, Priebe I, Belobrajdic D, Phatak A, Purins L . Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled. World J Gastroenterol. 2014; 20(4):888-98. PMC: 3921542. DOI: 10.3748/wjg.v20.i4.888. View

Wang R, Sun Q, Wang P, Liu M, Xiong S, Luo J . Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells. Oncotarget. 2016; 7(5):5754-68. PMC: 4868719. DOI: 10.18632/oncotarget.6805. View

10.

Wan D, Shen S, Fu S, Preston B, Brandon C, He S . miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. Anticancer Agents Med Chem. 2015; 16(4):414-23. DOI: 10.2174/1871520615666150716105955. View

11.

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

12.

Peng W, Gao W, Feng J . Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer. Med Oncol. 2014; 31(12):346. DOI: 10.1007/s12032-014-0346-4. View

13.

Saka M, Morita S, Fukagawa T, Katai H . Present and future status of gastric cancer surgery. Jpn J Clin Oncol. 2011; 41(3):307-13. DOI: 10.1093/jjco/hyq240. View

14.

Li S, Xu H, Yu Y, He J, Wang Z, Xu Y . LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway. Oncotarget. 2016; 7(27):42431-42446. PMC: 5173146. DOI: 10.18632/oncotarget.9883. View

15.

Uzan V, van Helvoort Lengert A, Boldrini E, Penna V, Scapulatempo-Neto C, Scrideli C . High Expression of HULC Is Associated with Poor Prognosis in Osteosarcoma Patients. PLoS One. 2016; 11(6):e0156774. PMC: 4890737. DOI: 10.1371/journal.pone.0156774. View

16.

Yang F, Zhang L, Huo X, Yuan J, Xu D, Yuan S . Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. 2011; 54(5):1679-89. DOI: 10.1002/hep.24563. View

17.

Iqbal J, Naushad H, Bi C, Yu J, Bouska A, Rohr J . Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?. Blood Rev. 2015; 30(2):73-88. DOI: 10.1016/j.blre.2015.08.002. View

18.

Tsai M, Manor O, Wan Y, Mosammaparast N, Wang J, Lan F . Long noncoding RNA as modular scaffold of histone modification complexes. Science. 2010; 329(5992):689-93. PMC: 2967777. DOI: 10.1126/science.1192002. View

19.

Sanulli S, Justin N, Teissandier A, Ancelin K, Portoso M, Caron M . Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Mol Cell. 2015; 57(5):769-783. PMC: 4352895. DOI: 10.1016/j.molcel.2014.12.020. View

20.

Tan P, Yeoh K . Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma. Gastroenterology. 2015; 149(5):1153-1162.e3. DOI: 10.1053/j.gastro.2015.05.059. View