Antihypertensive Effect of an Enzymatic Hydrolysate from Flesh Tissue in Type 2 Diabetic Patients with Hypertension

Overview

Journal Nutr Res Pract

Specialty Nutritional Sciences

Date 2017 Oct 10

PMID 28989576

Citations 7

Authors

Seok-Chun Ko

Won-Kyo Jung

Seung-Hong Lee

Dae Ho Lee

You-Jin Jeon

Affiliations

Soon will be listed here.

Abstract

Background/objectives: In this randomized, placebo-controlled, double-blind study, we evaluated the antihypertensive effects of enzymatic hydrolysate from flesh tissue in patients with type 2 diabetes mellitus (T2DM) and hypertension.

Subjects/methods: flesh tissue hydrolysate (SFTH) (n = 34) and placebo (n = 22) were randomly allocated to the study subjects. Each subject ingested two test capsules (500 mg) containing powdered SFTH (SFTH group) or placebo capsules (placebo group) during four weeks.

Results: In the SFTH group, systolic and diastolic blood pressure decreased significantly 4 weeks after ingestion by 9.9 mmHg ( < 0.01) and 7.8 mmHg ( < 0.01), respectively. In addition, the SFTH group exhibited a significant decrease in hemoglobin A with a tendency toward improvement in homeostasis model assessment of insulin resistance, triglyceride, apolipoprotein B and plasma insulin levels after 4 weeks. No adverse effects were observed in other indexes, including biochemical and hematological parameters in both groups.

Conclusion: The results of our study suggested that SFTH exerts a regulatory, antihypertensive effect in patients with T2DM and hypertension.

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