Usutu Virus in Cerebrospinal Fluid: A 2-year Survey in a Tertiary Care Hospital, Geneva, Switzerland

Overview

Journal J Med Virol

Specialty Microbiology

Date 2017 Oct 5

PMID 28976585

Citations 3

Authors

Samuel Cordey

Gael Vieille

Lara Turin

Laurent Kaiser

Affiliations

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Abstract

In 2009, the Usutu virus (USUV) was first reported as a cause of human neuroinvasive disorders. In Switzerland, USUV has been detected in wild birds with a seroprevalence of up to 6.59% in captive specimens sampled from zoo enclosures. This study investigates the clinical prevalence of USUV in human acute neuroinvasive disorders in Switzerland. Two hundred and fifty-eight cerebrospinal fluid samples collected between 2015 and 2017 for routine clinical care in a tertiary level hospital (Geneva) were tested for USUV by rRT-PCR. No samples were found positive, suggesting the absence, or the extremely low circulation of USUV in Western Switzerland.

Citing Articles

Epidemiology of Usutu Virus: The European Scenario.

Vilibic-cavlek T, Petrovic T, Savic V, Barbic L, Tabain I, Stevanovic V Pathogens. 2020; 9(9).

PMID: 32858963 PMC: 7560012. DOI: 10.3390/pathogens9090699.

Usutu Virus: An Arbovirus on the Rise.

Roesch F, Fajardo A, Moratorio G, Vignuzzi M Viruses. 2019; 11(7).

PMID: 31336826 PMC: 6669749. DOI: 10.3390/v11070640.

Usutu virus in cerebrospinal fluid: A 2-year survey in a Tertiary Care Hospital, Geneva, Switzerland.

Cordey S, Vieille G, Turin L, Kaiser L J Med Virol. 2017; 90(3):609-611.

PMID: 28976585 PMC: 5813136. DOI: 10.1002/jmv.24967.

References

Cadar D, Maier P, Muller S, Kress J, Chudy M, Bialonski A . Blood donor screening for West Nile virus (WNV) revealed acute Usutu virus (USUV) infection, Germany, September 2016. Euro Surveill. 2017; 22(14). PMC: 5388121. DOI: 10.2807/1560-7917.ES.2017.22.14.30501. View

Pecorari M, Longo G, Gennari W, Grottola A, Sabbatini A, Tagliazucchi S . First human case of Usutu virus neuroinvasive infection, Italy, August-September 2009. Euro Surveill. 2010; 14(50). View

Calzolari M, Chiapponi C, Bonilauri P, Lelli D, Baioni L, Barbieri I . Co-circulation of two Usutu virus strains in Northern Italy between 2009 and 2014. Infect Genet Evol. 2017; 51:255-262. DOI: 10.1016/j.meegid.2017.03.022. View

Schibler M, Yerly S, Vieille G, Docquier M, Turin L, Kaiser L . Critical analysis of rhinovirus RNA load quantification by real-time reverse transcription-PCR. J Clin Microbiol. 2012; 50(9):2868-72. PMC: 3421824. DOI: 10.1128/JCM.06752-11. View

Cavrini F, Gaibani P, Longo G, Pierro A, Rossini G, Bonilauri P . Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August-September 2009. Euro Surveill. 2010; 14(50). View

Nikolay B, Weidmann M, Dupressoir A, Faye O, Boye C, Diallo M . Development of a Usutu virus specific real-time reverse transcription PCR assay based on sequenced strains from Africa and Europe. J Virol Methods. 2013; 197:51-4. DOI: 10.1016/j.jviromet.2013.08.039. View

Cadar D, Luhken R, van der Jeugd H, Garigliany M, Ziegler U, Keller M . Widespread activity of multiple lineages of Usutu virus, western Europe, 2016. Euro Surveill. 2017; 22(4). PMC: 5388094. DOI: 10.2807/1560-7917.ES.2017.22.4.30452. View

Nikolay B, Diallo M, Boye C, Sall A . Usutu virus in Africa. Vector Borne Zoonotic Dis. 2011; 11(11):1417-23. DOI: 10.1089/vbz.2011.0631. View

Vilibic-cavlek T, Kaic B, Barbic L, Pem-Novosel I, Slavic-Vrzic V, Lesnikar V . First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak. Infection. 2014; 42(4):689-95. DOI: 10.1007/s15010-014-0625-1. View

10.

Grottola A, Marcacci M, Tagliazucchi S, Gennari W, Di Gennaro A, Orsini M . Usutu virus infections in humans: a retrospective analysis in the municipality of Modena, Italy. Clin Microbiol Infect. 2016; 23(1):33-37. DOI: 10.1016/j.cmi.2016.09.019. View

11.

Santini M, Vilibic-cavlek T, Barsic B, Barbic L, Savic V, Stevanovic V . First cases of human Usutu virus neuroinvasive infection in Croatia, August-September 2013: clinical and laboratory features. J Neurovirol. 2014; 21(1):92-7. DOI: 10.1007/s13365-014-0300-4. View

12.

Cadar D, Becker N, de Mendonca Campos R, Borstler J, Jost H, Schmidt-Chanasit J . Usutu virus in bats, Germany, 2013. Emerg Infect Dis. 2014; 20(10):1771-3. PMC: 4193186. DOI: 10.3201/eid2010.140909. View

13.

Steinmetz H, Bakonyi T, Weissenbock H, Hatt J, Eulenberger U, Robert N . Emergence and establishment of Usutu virus infection in wild and captive avian species in and around Zurich, Switzerland--genomic and pathologic comparison to other central European outbreaks. Vet Microbiol. 2010; 148(2-4):207-12. DOI: 10.1016/j.vetmic.2010.09.018. View

14.

Pierro A, Landini M, Gaibani P, Rossini G, Vocale C, Finarelli A . A model of laboratory surveillance for neuro-arbovirosis applied during 2012 in the Emilia-Romagna region, Italy. Clin Microbiol Infect. 2013; 20(7):672-7. DOI: 10.1111/1469-0691.12436. View

15.

Buchebner N, Zenker W, Wenker C, Steinmetz H, Sos E, Lussy H . Low Usutu virus seroprevalence in four zoological gardens in central Europe. BMC Vet Res. 2013; 9:153. PMC: 3750400. DOI: 10.1186/1746-6148-9-153. View

16.

Ashraf U, Ye J, Ruan X, Wan S, Zhu B, Cao S . Usutu virus: an emerging flavivirus in Europe. Viruses. 2015; 7(1):219-38. PMC: 4306835. DOI: 10.3390/v7010219. View

17.

Weissenbock H, Kolodziejek J, Fragner K, Kuhn R, Pfeffer M, Nowotny N . Usutu virus activity in Austria, 2001-2002. Microbes Infect. 2003; 5(12):1132-6. DOI: 10.1016/s1286-4579(03)00204-1. View

18.

Cordey S, Vieille G, Turin L, Kaiser L . Usutu virus in cerebrospinal fluid: A 2-year survey in a Tertiary Care Hospital, Geneva, Switzerland. J Med Virol. 2017; 90(3):609-611. PMC: 5813136. DOI: 10.1002/jmv.24967. View

19.

Cavrini F, Della Pepa M, Gaibani P, Pierro A, Rossini G, Landini M . A rapid and specific real-time RT-PCR assay to identify Usutu virus in human plasma, serum, and cerebrospinal fluid. J Clin Virol. 2010; 50(3):221-3. DOI: 10.1016/j.jcv.2010.11.008. View

20.

Allering L, Jost H, Emmerich P, Gunther S, Lattwein E, Schmidt M . Detection of Usutu virus infection in a healthy blood donor from south-west Germany, 2012. Euro Surveill. 2012; 17(50). View