Low Serum Levels of 25-Hydroxyvitamin D Are Associated with Stroke Recurrence and Poor Functional Outcomes in Patients with Ischemic Stroke

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2017 Oct 4

PMID 28972241

Citations 12

Authors

W Ji

H Zhou

S Wang

L Cheng

Y Fang

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the association between serum 25(OH) D levels and functional outcome and stroke recurrence events in a 6-month follow-up study in a cohort of patients with an acute ischemic stroke (AIS).

Methods: From March 2014 to August 2015, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum 25(OH) D levels were measured at admission. Functional outcome was evaluated at 6-month using the modified Rankin scale (m-Rankin). We used logistic regression models to assess the relationship between 25(OH) levels and risk of recurrent stroke or functional outcome.

Results: We recorded 277 stroke patients. There were significantly negative correlation between levels of 25(OH) D and NHISS (P<0.001), and the infarct volume (P< 0.001). Thirty-one patients (11.9%) had a stroke recurrence, while 82 patients (29.6) were with poor functional outcomes. In multivariate logistic regression analyses, serum 25(OH) D level was an independent marker of poor functional outcome and stroke recurrence [odds ratio (OR) 2.55 (1.38-3.96) and 3.03(1.65-4.12), respectively, P<0.001 for both, adjusted for NHISS, other predictors and vascular risk factors] in patients with AIS.

Conclusion: Our results demonstrate that low 25(OH) D levels are associated with stroke recurrence and support the hypothesis that 25(OH) D may serve as a biomarker of poor functional outcome after stroke.

Citing Articles

A systematic review and meta-analysis of the linkage between low vitamin D and the risk as well as the prognosis of stroke.

Xiong J, Zhao C, Li J, Li Y Brain Behav. 2024; 14(6):e3577.

PMID: 38873864 PMC: 11177038. DOI: 10.1002/brb3.3577.

Association between Vitamin D and Short-Term Functional Outcomes in Acute Ischemic Stroke.

Kim M, Lee J, Chung S, Soh Y Nutrients. 2023; 15(23).

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Effect of High-dose Vitamin D on IL-1β Blood Level in Patients with Moderate Stroke: A Randomized Clinical Trial.

Kouchek M, Shojaei S, Amniati S, Ghaffari M, Salarian S, Miri M Anesth Pain Med. 2023; 13(4):e138810.

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A systematic review examining the effect of vitamin D supplementation on functional outcomes post-stroke.

Fleet J, McIntyre A, Janzen S, Saikaley M, Qaqish M, Cianfarani R Clin Rehabil. 2023; 37(11):1451-1466.

PMID: 37166229 PMC: 10492437. DOI: 10.1177/02692155231174599.

25-Hydroxy-Vitamin D and Risk of Recurrent Stroke: A Dose Response Meta-Analysis.

Vergatti A, Abate V, Zarrella A, Manganelli F, Tozza S, Iodice R Nutrients. 2023; 15(3).

PMID: 36771220 PMC: 9921019. DOI: 10.3390/nu15030512.

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