Tumor Immunology Viewed from Alternative Animal Models-the Story

Overview

Journal Curr Pathobiol Rep

Specialty Pathology

Date 2017 Sep 26

PMID 28944105

Citations 9

Authors

Maureen Banach

Jacques Robert

Affiliations

Soon will be listed here.

Abstract

A Purpose Of Review: Nonmammalian comparative animal models are important not only to gain fundamental evolutionary understanding of the complex interactions of tumors with the immune system, but also to better predict the applicability of novel immunotherapeutic approaches to humans. After reviewing recent advances in developing alternative models, we focus on the amphibian and its usefulness in deciphering the perplexing roles of MHC class I-like molecules and innate (i)T cells in tumor immunity.

B Recent Findings: Experiments using MHC-defined inbred and cloned animals, tumor cell lines, effective reagents, sequenced genomes, and adapted gene editing techniques in , have revealed that the critical involvement of class I-like molecules and iT cells in tumor immunity has been conserved during evolution.

C Summary: Comparative studies with the tumor immunity model can contribute to the development of better and more efficient cancer immunotherapies.

Citing Articles

The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.

Sabino-Pinto J, Maan M J Mol Evol. 2025; 93(1):38-61.

PMID: 39774934 PMC: 11850509. DOI: 10.1007/s00239-024-10223-7.

Revealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis.

Ran R, Li L, Xu T, Huang J, He H, Chen Y Commun Biol. 2024; 7(1):275.

PMID: 38443437 PMC: 10915148. DOI: 10.1038/s42003-024-05967-3.

Alternatives of Animal Models for Biomedical Research: a Comprehensive Review of Modern Approaches.

Vashishat A, Patel P, Gupta G, Kurmi B Stem Cell Rev Rep. 2024; 20(4):881-899.

PMID: 38429620 DOI: 10.1007/s12015-024-10701-x.

Engraftment of Allotransplanted Tumor Cells in Adult Mutant .

Tulkens D, Dimitrakopoulou D, Boelens M, Van Nieuwenhuysen T, Demuynck S, Toussaint W Cancers (Basel). 2022; 14(19).

PMID: 36230482 PMC: 9559464. DOI: 10.3390/cancers14194560.

An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.

Herrera-Rincon C, Pare J, Martyniuk C, Jannetty S, Harrison C, Fischer A NPJ Regen Med. 2020; 5:2.

PMID: 32047653 PMC: 7000827. DOI: 10.1038/s41536-020-0087-2.

References

Krug U, Ganser A, Koeffler H . Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene. 2002; 21(21):3475-95. DOI: 10.1038/sj.onc.1205322. View

Reinardy H, Chapman J, Bodnar A . Induction of innate immune gene expression following methyl methanesulfonate-induced DNA damage in sea urchins. Biol Lett. 2016; 12(2):20151057. PMC: 4780559. DOI: 10.1098/rsbl.2015.1057. View

Stacy B, Parker J . Amphibian oncology. Vet Clin North Am Exot Anim Pract. 2004; 7(3):673-95, vi-vii. DOI: 10.1016/j.cvex.2004.04.001. View

Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J . Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer Res. 2014; 75(2):306-15. DOI: 10.1158/0008-5472.CAN-14-2819. View

Robert J . Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates. Dev Comp Immunol. 2010; 34(9):915-25. PMC: 2900388. DOI: 10.1016/j.dci.2010.05.011. View

Tandon P, Conlon F, Furlow J, Horb M . Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling. Dev Biol. 2016; 426(2):325-335. PMC: 5074924. DOI: 10.1016/j.ydbio.2016.04.009. View

Edholm E, Albertorio Saez L, Gill A, Gill S, Grayfer L, Haynes N . Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians. Proc Natl Acad Sci U S A. 2013; 110(35):14342-7. PMC: 3761575. DOI: 10.1073/pnas.1309840110. View

Chernet B, Adams D, Lobikin M, Levin M . Use of genetically encoded, light-gated ion translocators to control tumorigenesis. Oncotarget. 2016; 7(15):19575-88. PMC: 4991402. DOI: 10.18632/oncotarget.8036. View

Kjer-Nielsen L, Patel O, Corbett A, Le Nours J, Meehan B, Liu L . MR1 presents microbial vitamin B metabolites to MAIT cells. Nature. 2012; 491(7426):717-23. DOI: 10.1038/nature11605. View

10.

Aktipis C, Boddy A, Jansen G, Hibner U, Hochberg M, Maley C . Cancer across the tree of life: cooperation and cheating in multicellularity. Philos Trans R Soc Lond B Biol Sci. 2015; 370(1673). PMC: 4581024. DOI: 10.1098/rstb.2014.0219. View

11.

Stern A, Allison S, Chu C . Pancreatic carcinoma in an African clawed frog (Xenopus laevis). Comp Med. 2014; 64(6):421-3. PMC: 4275077. View

12.

Robertson F, Berzofsky J, Terabe M . NKT cell networks in the regulation of tumor immunity. Front Immunol. 2014; 5:543. PMC: 4211539. DOI: 10.3389/fimmu.2014.00543. View

13.

Garcia-Lora A, Algarra I, Garrido F . MHC class I antigens, immune surveillance, and tumor immune escape. J Cell Physiol. 2003; 195(3):346-55. DOI: 10.1002/jcp.10290. View

14.

Lu W, Amatruda J, Abrams J . p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer. 2009; 9(10):758-62. DOI: 10.1038/nrc2732. View

15.

Pilones K, Aryankalayil J, Demaria S . Invariant NKT cells as novel targets for immunotherapy in solid tumors. Clin Dev Immunol. 2012; 2012:720803. PMC: 3483734. DOI: 10.1155/2012/720803. View

16.

Session A, Uno Y, Kwon T, Chapman J, Toyoda A, Takahashi S . Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016; 538(7625):336-343. PMC: 5313049. DOI: 10.1038/nature19840. View

17.

Nedelkovska H, Edholm E, Haynes N, Robert J . Effective RNAi-mediated β2-microglobulin loss of function by transgenesis in Xenopus laevis. Biol Open. 2013; 2(3):335-42. PMC: 3603415. DOI: 10.1242/bio.20133483. View

18.

Robert J, Cohen N . Evolution of immune surveillance and tumor immunity: studies in Xenopus. Immunol Rev. 1999; 166:231-43. DOI: 10.1111/j.1600-065x.1998.tb01266.x. View

19.

Mizgirev I, Revskoy S . Generation of clonal zebrafish lines and transplantable hepatic tumors. Nat Protoc. 2010; 5(3):383-94. DOI: 10.1038/nprot.2010.8. View

20.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View