» Articles » PMID: 2893793

Primary Structure of Chicken Liver Acetyl-CoA Carboxylase Deduced from CDNA Sequence

Overview
Journal J Biol Chem
Specialty Biochemistry
Date 1988 Feb 25
PMID 2893793
Citations 36
Authors
Affiliations
Soon will be listed here.
Abstract

The complete amino acid sequence of acetyl-CoA carboxylase from chicken liver has been deduced by cloning and sequence analysis of DNA complementary to its messenger RNA. The results were confirmed by Edman degradation of peptide fragments obtained by digestion of the enzyme polypeptide with Achromobacter proteinase I or staphylococcal serine proteinase. Chicken liver acetyl-CoA carboxylase is predicted to be composed of 2,324 amino acid residues, having a calculated molecular weight of 262,706. The biotin carboxyl carrier protein domain is located in the middle region of the enzyme polypeptide. The amino-terminal portion of the acetyl-CoA carboxylase has been found to exhibit a homologous primary structure to that of carbamyl phosphate synthetase. Localization of possible functional domains including biotin carboxylase subsite in the acetyl-CoA carboxylase polypeptide is discussed.

Citing Articles

Further screening of SNP loci of eggshell translucency related genes and evaluation of genetic effects.

Liu G, Chen X, Liu X, Zhou R, Zhao X, Xu L Poult Sci. 2024; 103(9):103963.

PMID: 39013295 PMC: 11519685. DOI: 10.1016/j.psj.2024.103963.


Comparative Approach of the de novo Fatty Acid Synthesis (Lipogenesis) between Ruminant and Non Ruminant Mammalian Species: From Biochemical Level to the Main Regulatory Lipogenic Genes.

Laliotis G, Bizelis I, Rogdakis E Curr Genomics. 2010; 11(3):168-83.

PMID: 21037855 PMC: 2878982. DOI: 10.2174/138920210791110960.


Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.

Essop M, Camp H, Choi C, Sharma S, Fryer R, Reinhart G Am J Physiol Heart Circ Physiol. 2008; 295(1):H256-65.

PMID: 18487439 PMC: 2494759. DOI: 10.1152/ajpheart.91489.2007.


Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis.

Mao J, DeMayo F, Li H, Abu-Elheiga L, Gu Z, Shaikenov T Proc Natl Acad Sci U S A. 2006; 103(22):8552-7.

PMID: 16717184 PMC: 1570106. DOI: 10.1073/pnas.0603115103.


Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.

Abu-Elheiga L, Matzuk M, Kordari P, Oh W, Shaikenov T, Gu Z Proc Natl Acad Sci U S A. 2005; 102(34):12011-6.

PMID: 16103361 PMC: 1189351. DOI: 10.1073/pnas.0505714102.