MicroRNA-107-5p Suppresses Non-small Cell Lung Cancer by Directly Targeting Oncogene Epidermal Growth Factor Receptor

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 17

PMID 28915650

Citations 21

Authors

Ping Wang

Xiaomin Liu

Yang Shao

Huimin Wang

Chen Liang

Baohui Han

Zhongliang Ma

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are dysregulated in cancers, including human non-small cell lung cancer (NSCLC). The function of MicroRNA-107-5p (miR-107-5p) in NSCLC is not fully elucidated. Epidermal growth factor receptor (EGFR) is a cancer-driven gene in tumorigenesis. In this study, we found that miR-107-5p was significantly decreased in NSCLC tissues and NSCLC cell lines. Moreover, our results indicated that miR-107-5p could suppress cell proliferation, inhibit metastasis, impede cell cycle, and promote apoptosis via directly targeting EGFR. We also investigated roles of miR-107-5p . The results showed that it could inhibit tumor growth. Therefore, our study demonstrated that miR-107-5p not only suppressed the progression in NSCLC cells by inhibiting the expression of EGFR, but also could be a promising and a new potential therapeutic target for lung cancer.

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