Cryptotanshinone Suppresses Non-Small Cell Lung Cancer Via MicroRNA-146a-5p/EGFR Axis

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2019 Jun 12

PMID 31182926

Citations 20

Authors

Pengfei Qi

Yanli Li

Xiaomin Liu

Fatemeh A Jafari

Xinju Zhang

Qiangling Sun

Zhongliang Ma

Affiliations

Soon will be listed here.

Abstract

Epidermal growth factor receptor (EGFR), a cancer-driven gene, plays an important role in tumorigenesis of lung cancer. Cryptotanshinone (CT) is the main constituent of and has been found to affect tumor progression. However, the mechanism of CT on lung cancer is still not clear. Here we found that CT could suppress the proliferation of non-small cell lung cancer (NSCLC) by inhibiting EGFR. We further confirmed that knockdown of EGFR also suppressed cell proliferation and arrested cell cycle progression. Furthermore, we evaluated EGFR was a direct target gene of miR-146a-5p which was upregulated by CT. In general, our results proved that CT could restrain NSCLC via miR-146a-5p/EGFR axis. CT and miR-146a-5p have the potential to be positive candidates in drug development of NSCLC.

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