Downregulated MiR-18a and MiR-92a Synergistically Suppress Non-small Cell Lung Cancer Via Targeting

Overview

Journal Bioengineered

Date 2022 Apr 29

PMID 35484993

Authors

Xinju Zhang

Xianyi Wang

Binshu Chai

Zong Wu

Xiaomin Liu

Heng Zou

Ziyi Hua

Zhongliang Ma

Weiwei Wang

Affiliations

Soon will be listed here.

Abstract

As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseases, but the roles of miR-17-92 cluster in non-small cell lung cancer (NSCLC) have not been absolutely elaborated. Herein, we determined that miR-17-92 cluster were upregulated significantly in NSCLC tissues, and the cell proliferation, migration and cycle progression of NSCLC were also facilitated under the function of miR-17-92 cluster. () was a direct target of miR-92a, and its overexpression restrained the exacerbation of NSCLC induced by miR-92a. Furthermore, the tumor xenograft assay showed that miR-92a facilitated tumor growth by inhibiting the expression of SPRY4 and mediating Epithelial-Mesenchymal Transition (EMT) . Finally, we looked into the synergistic effects of miR-92a and miR-18a on NSCLC, and found that antagomiR-18a treatment arrested the tumor growth rate of xenografted mice markedly.

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