Inflammatory Markers As Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2017 Sep 13

PMID 28894464

Citations 10

Authors

A Rebonato

L Graziosi

D Maiettini

E Marino

V De Angelis

L Brunese

S Mosca

G Metro

M Rossi

G Orgera

M Scialpi

A Donini

Affiliations

Soon will be listed here.

Abstract

Introduction: Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma.

Methods: We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors.

Results: The global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS.

Conclusion: NLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment.

Citing Articles

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Inflammatory Scores: Comparison and Utility in HCC Patients Undergoing Transarterial Chemoembolization in a North American Cohort.

Young S, Cam I, Gencturk M, Rubin N, DSouza D, Flanagan S J Hepatocell Carcinoma. 2021; 8:1513-1524.

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References

Xu X, Chen W, Zhang L, Miao R, Zhou Y, Wan Y . Prognostic significance of neutrophil to lymphocyte ratio in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization. Chin Med J (Engl). 2014; 127(24):4204-9. View

Asher V, Lee J, Innamaa A, Bali A . Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer. Clin Transl Oncol. 2011; 13(7):499-503. DOI: 10.1007/s12094-011-0687-9. View

Arai K, Fukumoto T, Kido M, Tanaka M, Kuramitsu K, Kinoshita H . Preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after reductive surgery plus percutaneous isolated hepatic perfusion for hepatocellular carcinoma: a retrospective analysis. Surg Today. 2016; 47(3):385-392. DOI: 10.1007/s00595-016-1384-7. View

Zhang Y, Ma C, Wang M, Hou H, Cui L, Jiang C . Prognostic significance of immune cells in the tumor microenvironment and peripheral blood of gallbladder carcinoma patients. Clin Transl Oncol. 2016; 19(4):477-488. DOI: 10.1007/s12094-016-1553-6. View

Fan W, Zhang Y, Wang Y, Yao X, Yang J, Li J . Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of survival and metastasis for recurrent hepatocellular carcinoma after transarterial chemoembolization. PLoS One. 2015; 10(3):e0119312. PMC: 4351002. DOI: 10.1371/journal.pone.0119312. View

Gomez D, Farid S, Malik H, Young A, Toogood G, Lodge J . Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg. 2008; 32(8):1757-62. DOI: 10.1007/s00268-008-9552-6. View

Lencioni R, Llovet J . Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010; 30(1):52-60. DOI: 10.1055/s-0030-1247132. View

Neagoe P, Brkovic A, Hajjar F, Sirois M . Expression and release of angiopoietin-1 from human neutrophils: intracellular mechanisms. Growth Factors. 2009; 27(6):335-44. DOI: 10.3109/08977190903155043. View

Wang D, Ren C, Qiu M, Luo H, Wang Z, Zhang D . Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer. Tumour Biol. 2011; 33(3):749-56. DOI: 10.1007/s13277-011-0285-z. View

10.

Satomi A, Murakami S, Ishida K, Mastuki M, Hashimoto T, Sonoda M . Significance of increased neutrophils in patients with advanced colorectal cancer. Acta Oncol. 1995; 34(1):69-73. DOI: 10.3109/02841869509093641. View

11.

Shau H, Kim A . Suppression of lymphokine-activated killer induction by neutrophils. J Immunol. 1988; 141(12):4395-402. View

12.

Jin H, Sun J, Zhu K, Liu X, Zhang Q, Shen Q . The prognostic value of neutrophil-lymphocyte ratio is superior to derived neutrophil-lymphocyte ratio in advanced gastric cancer treated with preoperative chemotherapy and sequential R0 resection: a 5-year follow-up. Onco Targets Ther. 2017; 10:2655-2664. PMC: 5449100. DOI: 10.2147/OTT.S135641. View

13.

Walsh S, Cook E, Goulder F, Justin T, Keeling N . Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol. 2005; 91(3):181-4. DOI: 10.1002/jso.20329. View

14.

Wang C, Sun C . C-reactive protein and malignancy: clinico-pathological association and therapeutic implication. Chang Gung Med J. 2009; 32(5):471-82. View

15.

Tuszynski G, Nicosia R . The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays. 1996; 18(1):71-6. DOI: 10.1002/bies.950180113. View

16.

Liao R, Tang Z, Li D, Luo S, Huang P, Du C . Preoperative neutrophil-to-lymphocyte ratio predicts recurrence of patients with single-nodule small hepatocellular carcinoma following curative resection: a retrospective report. World J Surg Oncol. 2015; 13:265. PMC: 4557750. DOI: 10.1186/s12957-015-0670-y. View

17.

Maltoni M, Caraceni A, Brunelli C, Broeckaert B, Christakis N, Eychmueller S . Prognostic factors in advanced cancer patients: evidence-based clinical recommendations--a study by the Steering Committee of the European Association for Palliative Care. J Clin Oncol. 2005; 23(25):6240-8. DOI: 10.1200/JCO.2005.06.866. View

18.

Bhatti I, Peacock O, Lloyd G, Larvin M, Hall R . Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio. Am J Surg. 2010; 200(2):197-203. DOI: 10.1016/j.amjsurg.2009.08.041. View

19.

Balkwill F, Mantovani A . Inflammation and cancer: back to Virchow?. Lancet. 2001; 357(9255):539-45. DOI: 10.1016/S0140-6736(00)04046-0. View

20.

Ietomi K . [A study on the role of granulocytes in carcinoma-bearing hosts--G/L ratio as a new host indicator]. Nihon Gan Chiryo Gakkai Shi. 1990; 25(3):662-71. View