Preoperative Neutrophil-to-lymphocyte Ratio Predicts Recurrence of Patients with Single-nodule Small Hepatocellular Carcinoma Following Curative Resection: a Retrospective Report

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2015 Sep 3

PMID 26328917

Citations 22

Authors

Rui Liao

Zhuo-Wei Tang

De-Wei Li

Shi-Qiao Luo

Ping Huang

Cheng-You Du

Affiliations

Soon will be listed here.

Abstract

Background: Preoperative neutrophil-to-lymphocyte ratio (NLR) has been identified as a predictor for the recurrence of hepatocellular carcinoma (HCC), but the cut-off of NLR is inconsistent in various studies. Thus, we detected the prognostic value of preoperative NLR in the single-nodule small HCC (SHCC) patients using X-tile for cutpoint.

Methods: Between January 2007 and December 2010, a total of 222 single-nodule SHCC patients underwent curative resection and were examined for the prognostic roles of preoperative NLR by X-tile.

Results: In this study, all patients were divided into the low-NLR subgroup (NLR ≤ 2.1) and the high-NLR subgroup (NLR > 2.1) by X-tile. Preoperative NLR showed predictive value for time to recurrence (TTR) and overall survival (OS). Moreover, NLR was associated with total bilirubin, white blood cell counts, and HBsAg, respectively (P = 0.012, <0.001, and 0.011, respectively). Especially, NLR could discriminate the outcome of patients in the subgroup with alpha-fetoprotein (AFP) levels of ≤400 ng/mL. Importantly, postoperative transcatheter arterial chemoembolization (TACE) had close relationship with OS (P = 0.001) and TTR (P ≤ 0.001).

Conclusions: Therefore, this study indicates that preoperative NLR, divided by X-tile for the cutpoint, is a simple prognostic marker for the patients with single-nodule SHCC after curative resection.

Citing Articles

[The Value of Clinical Characteristics and Hematological Parameters for Prognostic Assessment of Pancreatic Cancer Patients Undergoing Radical Resection].

Zeng L, Li S, Yue P, Yi C Sichuan Da Xue Xue Bao Yi Xue Ban. 2024; 55(3):708-716.

PMID: 38948268 PMC: 11211788. DOI: 10.12182/20240560604.

Preoperative contrast-enhanced computed tomography-based radiomics model for overall survival prediction in hepatocellular carcinoma.

Deng P, Zhao B, Huang X, Xu T, Chen Z, Wei Q World J Gastroenterol. 2022; 28(31):4376-4389.

PMID: 36159012 PMC: 9453776. DOI: 10.3748/wjg.v28.i31.4376.

Preoperative inflammatory markers as prognostic predictors after hepatocellular carcinoma resection: data from a western referral center.

Silva J, Coelho F, Cassenote A, Jeismann V, Fonseca G, Pirola Kruger J BMC Surg. 2022; 22(1):329.

PMID: 36056350 PMC: 9440527. DOI: 10.1186/s12893-022-01779-6.

Immunological Markers, Prognostic Factors and Challenges Following Curative Treatments for Hepatocellular Carcinoma.

Lee S, Lee S, Jang J, Bae S, Choi J, Yoon S Int J Mol Sci. 2021; 22(19).

PMID: 34638613 PMC: 8508906. DOI: 10.3390/ijms221910271.

Neutrophil-to-lymphocyte ratio as a prognostic biomarker in hepatocellular carcinoma after transarterial chemoembolization.

Jeong S Ann Transl Med. 2020; 8(18):1124.

PMID: 33240973 PMC: 7576090. DOI: 10.21037/atm-20-4296.

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