Neutrophil-lymphocyte Ratio As a Prognostic Factor in Colorectal Cancer

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2005 Aug 25

PMID 16118772

Citations 472

Authors

S R Walsh

E J Cook

F Goulder

T A Justin

N J Keeling

Affiliations

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Abstract

Background And Objectives: Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients.

Methods: Two-hundred thirty patients diagnosed with colorectal cancer over a two-year period were identified from a prospectively maintained colorectal cancer database. NLR was calculated from pre-operative full blood counts. In the case of patients who did not undergo surgery, the full blood count from their out-patient visit was used. Known prognostic factors were recorded. Overall and cancer-specific survival were calculated.

Results: Pre-operative NLR greater than 5 correlated with overall and cancer-specific survival in univariate analyses. NLR was not independent of Dukes stage.

Conclusions: Pre-operative NLR may represent a simple method of identifying colorectal cancer patients with a poor prognosis pre-operatively.

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